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  • Olfactory Ensheathing Cells for Spinal Cord Injury: Sniffing Out the Issues

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    Version of Record (VoR)
    Author(s)
    Yao, R
    Murtaza, M
    Velasquez, J Tello
    Todorovic, M
    Rayfield, A
    Ekberg, J
    Barton, M
    St John, J
    Griffith University Author(s)
    Todorovic, Michael
    St John, James A.
    Ekberg, Jenny A.
    Rayfield, Andrew J.
    Murtaza, Mariyam
    Barton, Matthew J.
    Year published
    2018
    Metadata
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    Abstract
    Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction). Due to this distinctive property, OECs have been trialed in human cell transplant therapies to assist in the repair of central nervous system injuries, particularly those of the spinal cord. Though many studies have reported neurological improvement, the therapy remains inconsistent and requires further improvement. Much of this variability stems from differing olfactory cell populations prior to transplantation ...
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    Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction). Due to this distinctive property, OECs have been trialed in human cell transplant therapies to assist in the repair of central nervous system injuries, particularly those of the spinal cord. Though many studies have reported neurological improvement, the therapy remains inconsistent and requires further improvement. Much of this variability stems from differing olfactory cell populations prior to transplantation into the injury site. While some studies have used purified cells, others have used unpurified transplants. Although both preparations have merits and faults, the latter increases the variability between transplants received by recipients. Without a robust purification procedure in OEC transplantation therapies, the full potential of OECs for spinal cord injury may not be realised.
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    Journal Title
    Cell Transplantation
    Volume
    27
    Issue
    6
    DOI
    https://doi.org/10.1177/0963689718779353
    Copyright Statement
    © 2018 Cognizant Communication Corporation. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological sciences
    Other biological sciences not elsewhere classified
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/382147
    Collection
    • Journal articles

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