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dc.contributor.authorMarchant, Julieen_US
dc.contributor.authorPetsky, Helenen_US
dc.contributor.authorMorris, Peteren_US
dc.contributor.authorChang, Anneen_US
dc.date.accessioned2019-05-29T13:10:35Z
dc.date.available2019-05-29T13:10:35Z
dc.date.issued2018en_US
dc.identifier.issn1469-493Xen_US
dc.identifier.doi10.1002/14651858.CD004822.pub3en_US
dc.identifier.urihttp://hdl.handle.net/10072/382153
dc.description.abstractBackground: Cough is a frequent symptom presenting to doctors. Themost common cause of childhood chronic (greater than fours weeks’ duration) wet cough is protracted bacterial bronchitis (PBB) in some settings, although othermore serious causes can also present this way. Timely and effective management of chronic wet or productive cough improves quality of life and clinical outcomes. Current international guidelines suggest a course of antibiotics is the first treatment of choice in the absence of signs or symptoms specific to an alternative diagnosis. This review sought to clarify the current evidence to support this recommendation. Objectives: To determine the efficacy of antibiotics in treating children with prolonged wet cough (excluding children with bronchiectasis or other known underlying respiratory illness) and to assess risk of harm due to adverse events. Search methods: We undertook an updated search (from 2008 onwards) using the Cochrane Airways Group Specialised Register, Cochrane Register of Controlled Trials (CENTRAL), MEDLINE, Embase, trials registries, review articles and reference lists of relevant articles. The latest searches were performed in September 2017. Selection criteria: We included randomised controlled trials (RCTs) comparing antibiotics with a placebo or a control group in children with chronic wet cough. We excluded cluster and cross-over trials. Data collection and analysis: We used standard methods as recommended by Cochrane.We reviewed results of searches against predetermined criteria for inclusion. Two independent review authors selected, extracted and assessed the data for inclusion. We contacted authors of eligible studies for further information as needed. We analysed data as ’intention to treat.’en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherJohn Wiley & Sonsen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto45en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalCochrane Database of Systematic Reviewsen_US
dc.relation.ispartofvolume2018en_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode119999en_US
dc.subject.fieldofresearchcode11en_US
dc.titleAntibiotics for prolonged wet cough in childrenen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPublisheden_US
gro.rights.copyright© 2018 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2018, 7. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.en_US
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