dc.contributor.author | Brown, Catherine A | |
dc.contributor.author | Youlden, Danny R | |
dc.contributor.author | Aitken, Joanne F | |
dc.contributor.author | Moore, Andrew S | |
dc.date.accessioned | 2019-06-07T01:44:06Z | |
dc.date.available | 2019-06-07T01:44:06Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1545-5009 | |
dc.identifier.doi | 10.1002/pbc.27410 | |
dc.identifier.uri | http://hdl.handle.net/10072/382185 | |
dc.description.abstract | Background
Therapy‐related acute myeloid leukemia (t‐AML) is defined as AML that develops after exposure to cytotoxic chemotherapy and/or radiation therapy. There is a paucity of available literature, particularly in regard to t‐AML following childhood cancer. Our aim was to describe the risk of t‐AML among children treated for other cancers and their subsequent survival.
Procedure
We utilized data from the population‐based Australian Childhood Cancer Registry to examine all childhood patients (<15 years at diagnosis) treated with chemotherapy and/or radiotherapy for cancers other than AML who received a subsequent diagnosis of AML between 1983 and 2014. Standardized incidence ratios (SIRs) were calculated to approximate the relative risk of being diagnosed with AML compared to the general population. Estimates of 5‐year observed survival were obtained using the Kaplan‐Meier method, with differences determined by the log‐rank test.
Results
Fifty‐eight of 11,753 patients in the study cohort (0.5%) were diagnosed with t‐AML, an almost 50‐fold higher risk than expected (SIR = 45.6, 95% confidence interval [CI] = 35.3‐59.0). Five‐year observed survival from the date of t‐AML diagnosis was 31.2% (95% CI = 19.6‐43.5%). A significant survival advantage was found for patients who underwent hematopoietic stem cell transplantation (HSCT) following diagnosis of t‐AML, with a 5‐year survival of 52.4% (29.7‐70.9%) compared to 5.7% (0.4‐22.6%) for those who did not have HSCT (P < 0.001).
Conclusions
Although rare, t‐AML is an important potential late effect of childhood cancer therapy. Prognosis is generally poor, with HSCT offering some survival benefit. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | John Wiley & Sons | |
dc.publisher.place | United States | |
dc.relation.ispartofpagefrom | 1 | |
dc.relation.ispartofpageto | 7 | |
dc.relation.ispartofissue | 12 | |
dc.relation.ispartofjournal | Pediatric Blood & Cancer | |
dc.relation.ispartofvolume | 65 | |
dc.subject.fieldofresearch | Clinical Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Oncology and Carcinogenesis | |
dc.subject.fieldofresearch | Paediatrics and Reproductive Medicine | |
dc.subject.fieldofresearchcode | 110399 | |
dc.subject.fieldofresearchcode | 1112 | |
dc.subject.fieldofresearchcode | 1114 | |
dc.subject.keywords | Australia | |
dc.subject.keywords | Population‐based | |
dc.subject.keywords | Relative risk | |
dc.subject.keywords | Survival | |
dc.subject.keywords | Therapy‐related acute myeloid leukemia | |
dc.title | Therapy-related acute myeloid leukemia following treatment for cancer in childhood: A population-based registry study | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2018 Wiley Periodicals Inc. This is the peer reviewed version of the following article: Therapy-related acute myeloid leukemia following treatment for cancer in childhood: A population-based registry study, Pediatric Blood & Cancer, Vol. 65, issue 12, pp. e27410-1 - e27410-7, 2018., which has been published in final form at 10.1002/pbc.27410. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html) | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Aitken, Joanne | |
gro.griffith.author | Youlden, Danny R. | |