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dc.contributor.authorMohamed, Ahmed
dc.contributor.authorShah, Anup D
dc.contributor.authorChen, David
dc.contributor.authorHill, Michelle M
dc.date.accessioned2019-05-29T12:41:45Z
dc.date.available2019-05-29T12:41:45Z
dc.date.issued2019
dc.identifier.issn0305-1048
dc.identifier.doi10.1093/nar/gky948
dc.identifier.urihttp://hdl.handle.net/10072/382190
dc.description.abstractCellular membranes feature dynamic submicrometer-scale lateral domains termed lipid rafts, membrane rafts or glycosphingolipid-enriched microdomains (GEM). Numerous proteomics studies have been conducted on the lipid raft proteome, however, interpretation of individual studies is limited by potential undefined contaminant proteins. To enable integrated analyses, we previously developed RaftProt (http://lipid-raft-database.di.uq.edu.au/), a searchable database of mammalian lipid raftassociated proteins. Despite being a highly used resource, further developments in annotation and utilities were required. Here, we present RaftProt V2 (http://raftprot.org), an improved update of Raft- Prot. Besides the addition of new datasets and re-mapping of all entries to both UniProt and UniRef IDs, we have implemented a stringent annotation based on experimental evidence level to assist in identification of possible contaminant proteins. Raft- Prot V2 allows for simultaneous search of multiple proteins/experiments at the cell/tissue type and UniRef/Gene level, where correlations, interactions or overlaps can be investigated. The web-interface has been completely re-designed to enable interactive data and subset selection, correlation analysis and network visualization. Overall, RaftProt aims to advance our understanding of lipid raft function through integrative analysis of datasets collected from diverse tissue and conditions. Database URL: http://raftprot.org.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherOxford University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom459
dc.relation.ispartofpageto463
dc.relation.ispartofjournalNucleic Acids Research
dc.relation.ispartofvolume47
dc.subject.fieldofresearchTechnology not elsewhere classified
dc.subject.fieldofresearchEnvironmental Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchInformation and Computing Sciences
dc.subject.fieldofresearchcode109999
dc.subject.fieldofresearchcode05
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode08
dc.titleRaftProt V2: understanding membrane microdomain function through lipid raft proteomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionPublished
gro.rights.copyrightThe Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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gro.griffith.authorChen, David


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