dc.contributor.author | Du Preez, S | |
dc.contributor.author | Corbitt, M | |
dc.contributor.author | Cabanas, H | |
dc.contributor.author | Eaton, N | |
dc.contributor.author | Staines, D | |
dc.contributor.author | Marshall-Gradisnik, S | |
dc.date.accessioned | 2019-06-06T01:33:24Z | |
dc.date.available | 2019-06-06T01:33:24Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2046-4053 | |
dc.identifier.doi | 10.1186/s13643-018-0909-0 | |
dc.identifier.uri | http://hdl.handle.net/10072/382199 | |
dc.description.abstract | Background:
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation.
Methods:
EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.
Results:
Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist.
Conclusions:
There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 1 | |
dc.relation.ispartofpageto | 12 | |
dc.relation.ispartofissue | 241 | |
dc.relation.ispartofjournal | Systematic Reviews | |
dc.relation.ispartofvolume | 7 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Cellular immunology | |
dc.subject.fieldofresearch | Immunology not elsewhere classified | |
dc.subject.fieldofresearch | Health sciences | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 320404 | |
dc.subject.fieldofresearchcode | 320499 | |
dc.subject.fieldofresearchcode | 42 | |
dc.title | A Systematic Review of Enteric Dysbiosis in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/4.0 | |
dc.description.version | Version of Record (VoR) | |
gro.faculty | An Unassigned Group, An Unassigned Department | |
gro.rights.copyright | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Staines, Donald R. | |
gro.griffith.author | Marshall-Gradisnik, Sonya M. | |
gro.griffith.author | Eaton-Fitch, Natalie R. | |