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dc.contributor.authorDu Preez, S
dc.contributor.authorCorbitt, M
dc.contributor.authorCabanas, H
dc.contributor.authorEaton, N
dc.contributor.authorStaines, D
dc.contributor.authorMarshall-Gradisnik, S
dc.date.accessioned2019-06-06T01:33:24Z
dc.date.available2019-06-06T01:33:24Z
dc.date.issued2018
dc.identifier.issn2046-4053
dc.identifier.doi10.1186/s13643-018-0909-0
dc.identifier.urihttp://hdl.handle.net/10072/382199
dc.description.abstractBackground: Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. Methods: EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported. Results: Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist. Conclusions: There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto12
dc.relation.ispartofissue241
dc.relation.ispartofjournalSystematic Reviews
dc.relation.ispartofvolume7
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode11
dc.titleA Systematic Review of Enteric Dysbiosis in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0
dc.description.versionPublished
gro.facultyAn Unassigned Group, An Unassigned Department
gro.rights.copyrightThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorStaines, Don R.
gro.griffith.authorCorbitt, Matthew J.
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorDu Preez, Stanley
gro.griffith.authorCabanas, Helene
gro.griffith.authorEaton-Fitch, Natalie R.


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