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dc.contributor.authorSingh, Kuljiten_US
dc.contributor.authorCarson, Kristinen_US
dc.contributor.authorRashid, Mohammeden_US
dc.contributor.authorJayasinghe, Rohanen_US
dc.contributor.authorAlQahtani, Abdulrahmanen_US
dc.contributor.authorDick, Alexanderen_US
dc.contributor.authorGlover, Christopheren_US
dc.contributor.authorLabinaz, Marinoen_US
dc.description.abstractBackground: Recent data from randomised and observational studies have reported non-inferior outcomes for transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve replacement (SAVR) in intermediate-risk patients. We performed a systematic review to evaluate the mortality of TAVI compared to SAVR in intermediate-risk patients. Methods: A comprehensive search of four major databases (Embase, Ovid MEDLINE, PubMed, and Google Scholar) was performed from their inception to 29 April 2016. We included original research studies reporting data on TAVI and SAVR in intermediate-risk patients. We compared the outcomes of TAVI to SAVR. Results: A total of 2,375 and 2,377 intermediate-risk patients underwent TAVI and SAVR respectively. The 30-day all-cause (p = 0.07), 30-day cardiac (p = 0.53), and 12-month all-cause mortality (p = 0.34) was similar between the two groups. However, TAVI through transfemoral access had a significantly lower mortality than SAVR (OR 0.58, p = 0.006). The incidence of ≥moderate aortic incompetence (p < 0.00001) and pacemaker implantation (p < 0.0001) was higher in the TAVI group. Conclusions: In the intermediate-risk patients, the 30-day and 12-month mortality are similar between TAVI and SAVR. Increased operator experience and improved device technology have led to a significant reduction in mortality in intermediate-risk patients undergoing TAVI.en_US
dc.publisherElsevier Australiaen_US
dc.relation.ispartofjournalHeart, Lung and Circulationen_US
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology not elsewhere classifieden_US
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematologyen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.titleTranscatheter Aortic Valve Implantation in Intermediate Surgical Risk Patients With Severe Aortic Stenosis: A Systematic Review and Meta-Analysisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medicineen_US
gro.hasfulltextNo Full Text

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