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dc.contributor.authorLai, Wenjingen_US
dc.contributor.authorCock, Ianen_US
dc.contributor.authorCheesman, Matthewen_US
dc.date.accessioned2019-05-29T12:42:13Z
dc.date.available2019-05-29T12:42:13Z
dc.date.issued2018en_US
dc.identifier.issn2249-0167en_US
dc.identifier.doi10.5530/pc.2018.4.33en_US
dc.identifier.urihttp://hdl.handle.net/10072/382350
dc.description.abstractBackground: The aim of this project was to investigate the efficacy of Astragalus membranaceus (Astragalus) extracts, alone and in combination with conventional antibiotics, against diarrhoea- and dysentery-causing pathogens, as well as against non-pathogenic gastrointestinal bacterial strains. The study sought to validate the chemotherapeutic potential of a traditional Chinese medicinal plant and to identify combinational therapies with increased efficacy compared to either the extracts or conventional antibiotics alone. Methods: Astragalus root powder was extracted with solvents of varying polarity and screened for inhibition of bacterial growth. Susceptibility was assessed by disc diffusion techniques, whilst the minimum inhibitory concentrations (MICs) were quantified by liquid dilution assays. To screen for combinatorial effects, the Astragalus root extracts were combined with a range of conventional antibiotics and tested against each bacterial strain using liquid dilution assays. ΣFIC values were determined and used to determine the class of interaction. Results: Aqueous Astragalus root extracts did not significantly inhibit the growth of the non-pathogenic or beneficial gut microflora bacteria E. cloacae, E. coli or E. faecalis, but possessed mild inhibitory activity against pathogenic A. faecalis, A. hydrophila, B. cereus, S. newport and S. sonnei bacteria. Combinations of the Astragalus extracts and conventional antibiotics generally produced additive or indifferent interactions, indicating that they are safe to use concomitantly without compromising the efficacy of either component. Two cases of antagonistic combinations were detected against B. cereus and S. sonnei. Conclusion: Mild inhibition of 5 pathogenic bacteria occurred with aqueous Astragalus extracts, with a number of additive and antagonistic interactions arising when tested in combination with conventional antibiotics. Astragalus may be used safely in the presence of normal gut bacteria and in most combinations with conventional antibiotics.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPharmocognosy Network Worldwideen_US
dc.publisher.placeIndiaen_US
dc.relation.ispartofpagefrom158en_US
dc.relation.ispartofpageto164en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalPharmacognosy Communicationsen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchTraditional Chinese Medicine and Treatmentsen_US
dc.subject.fieldofresearchcode110404en_US
dc.titleInteractive Antimicrobial Profiles of Astragalus membranaceus (Fisch.) Bunge Extracts and Conventional Antibiotics against Pathogenic and Non-pathogenic Gastrointestinal Bacteriaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.description.versionPublisheden_US
gro.facultyAn Unassigned Group, An Unassigned Departmenten_US
gro.rights.copyright© The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
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gro.griffith.authorLai, Wenjing
gro.griffith.authorCock, Ian E.
gro.griffith.authorCheesman, Matthew


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