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dc.contributor.authorO'Grady, Kerry-Annen_US
dc.contributor.authorCripps, Allanen_US
dc.contributor.authorGrimwood, Keithen_US
dc.date.accessioned2019-05-29T13:16:43Z
dc.date.available2019-05-29T13:16:43Z
dc.date.issued2019en_US
dc.identifier.issn1323-7799en_US
dc.identifier.doi10.1111/resp.13446en_US
dc.identifier.urihttp://hdl.handle.net/10072/382386
dc.description.abstractBronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. The evidence for the efficacy and effectiveness of these vaccines in both preventing and managing bronchiectasis in children and adults is limited with the focus of most research being on other chronic lung disorders, such as chronic obstructive pulmonary diseases, asthma and cystic fibrosis. We review the existing evidence for these vaccines in bronchiectasis and highlight the existing gaps in knowledge. High‐quality experimental and non‐experimental studies using current state‐of‐the‐art microbiological methods and validated, standardised case definitions are needed across the depth and breadth of the vaccine development pathway.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherWiley-Blackwell Publishing Asiaen_US
dc.publisher.placeAustraliaen_US
dc.relation.ispartofpagefrom107en_US
dc.relation.ispartofpageto114en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalRespirologyen_US
dc.relation.ispartofvolume24en_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode119999en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.keywordsAdultsen_US
dc.subject.keywordsBronchiectasisen_US
dc.subject.keywordsChildrenen_US
dc.subject.keywordsVaccinesen_US
dc.titlePaediatric and adult bronchiectasis: Vaccination in prevention and managementen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text


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