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dc.contributor.authorO'Grady, Kerry-Ann F
dc.contributor.authorCripps, Allan W
dc.contributor.authorGrimwood, Keith
dc.date.accessioned2019-05-29T13:16:43Z
dc.date.available2019-05-29T13:16:43Z
dc.date.issued2019
dc.identifier.issn1323-7799
dc.identifier.doi10.1111/resp.13446
dc.identifier.urihttp://hdl.handle.net/10072/382386
dc.description.abstractBronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. The evidence for the efficacy and effectiveness of these vaccines in both preventing and managing bronchiectasis in children and adults is limited with the focus of most research being on other chronic lung disorders, such as chronic obstructive pulmonary diseases, asthma and cystic fibrosis. We review the existing evidence for these vaccines in bronchiectasis and highlight the existing gaps in knowledge. High‐quality experimental and non‐experimental studies using current state‐of‐the‐art microbiological methods and validated, standardised case definitions are needed across the depth and breadth of the vaccine development pathway.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley-Blackwell Publishing Asia
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom107
dc.relation.ispartofpageto114
dc.relation.ispartofissue2
dc.relation.ispartofjournalRespirology
dc.relation.ispartofvolume24
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode11
dc.subject.keywordsAdults
dc.subject.keywordsBronchiectasis
dc.subject.keywordsChildren
dc.subject.keywordsVaccines
dc.titlePaediatric and adult bronchiectasis: Vaccination in prevention and management
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorGrimwood, Keith


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