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  • Megahertz serial crystallography

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    Author(s)
    Wiedorn, Max O
    Oberthuer, Dominik
    Bean, Richard
    Schubert, Robin
    Werner, Nadine
    Abbey, Brian
    Aepfelbacher, Martin
    Adriano, Luigi
    Allahgholi, Aschkan
    Al-Qudami, Nasser
    Andreasson, Jakob
    Aplin, Steve
    Awel, Salah
    Ayyer, Kartik
    Bajt, Sasa
    Barak, Imrich
    Bari, Sadia
    Bielecki, Johan
    Botha, Sabine
    Boukhelef, Djelloul
    Brehm, Wolfgang
    Brockhauser, Sandor
    Cheviakov, Igor
    Coleman, Matthew A
    Cruz-Mazo, Francisco
    Danilevski, Cyril
    Darmanin, Connie
    Doak, R Bruce
    Domaracky, Martin
    Doerner, Katerina
    Du, Yang
    Fangohr, Hans
    Fleckenstein, Holger
    Frank, Matthias
    Fromme, Petra
    Ganan-Calvo, Alfonso M
    Gevorkov, Yaroslav
    Giewekemeyer, Klaus
    Ginn, Helen Mary
    Graafsma, Heinz
    Graceffa, Rita
    Greiffenberg, Dominic
    Gumprecht, Lars
    Goettlicher, Peter
    Hajdu, Janos
    Hauf, Steffen
    Heymann, Michael
    Holmes, Susannah
    Horke, Daniel A
    Hunter, Mark S
    Imlau, Siegfried
    Kaukher, Alexander
    Kim, Yoonhee
    Klyuev, Alexander
    Knoska, Juraj
    Kobe, Bostjan
    Kuhn, Manuela
    Kupitz, Christopher
    Kuepper, Jochen
    Lahey-Rudolph, Janine Mia
    Laurus, Torsten
    Le Cong, Karoline
    Letrun, Romain
    Xavier, P Lourdu
    Maia, Luis
    Maia, Filipe RNC
    Mariani, Valerio
    Messerschmidt, Marc
    Metz, Markus
    Mezza, Davide
    Michelat, Thomas
    Mills, Grant
    Monteiro, Diana CF
    Morgan, Andrew
    Muhlig, Kerstin
    Munke, Anna
    Muennich, Astrid
    Nette, Julia
    Nugent, Keith A
    Nuguid, Theresa
    Orville, Allen M
    Pandey, Suraj
    Pena, Gisel
    Villanueva-Perez, Pablo
    Poehlsen, Jennifer
    Previtali, Gianpietro
    Redecke, Lars
    Riekehr, Winnie Maria
    Rohde, Holger
    Round, Adam
    Safenreiter, Tatiana
    Sarrou, Iosifina
    Sato, Tokushi
    Schmidt, Marius
    Schmitt, Bernd
    Schoenherr, Robert
    Schulz, Joachim
    Sellberg, Jonas A
    Seibert, M Marvin
    Seuring, Carolin
    Shelby, Megan L
    Shoeman, Robert L
    Sikorski, Marcin
    Silenzi, Alessandro
    Stan, Claudiu A
    Shi, Xintian
    Stern, Stephan
    Sztuk-Dambietz, Jola
    Szuba, Janusz
    Tolstikova, Aleksandra
    Trebbin, Martin
    Trunk, Ulrich
    Vagovic, Patrik
    Ve, Thomas
    Weinhausen, Britta
    White, Thomas A
    Wrona, Krzysztof
    Xu, Chen
    Yefanov, Oleksandr
    Zatsepin, Nadia
    Zhang, Jiaguo
    Perbandt, Markus
    Mancuso, Adrian P
    Betzel, Christian
    Chapman, Henry
    Barty, Anton
    Griffith University Author(s)
    Ve, Thomas
    Year published
    2018
    Metadata
    Show full item record
    Abstract
    The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex ...
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    The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
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    Journal Title
    Nature Communications
    Volume
    9
    DOI
    https://doi.org/10.1038/s41467-018-06156-7
    Copyright Statement
    Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2018 NATURE COMMUNICATIONS | (2018) 9:4025 | DOI: 10.1038/s41467-018-06156-7 | www.nature.com/naturecommunications 9
    Subject
    Molecular medicine
    Megahertz pulse
    Crystallography
    Serial femtosecond crystallography (SFX)
    Publication URI
    http://hdl.handle.net/10072/382410
    Collection
    • Journal articles

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