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dc.contributor.authorHubackova, Sona
dc.contributor.authorNovais, Silvia Magalhaes
dc.contributor.authorDavidova, Eliska
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorRohlena, Jakub
dc.date.accessioned2019-07-05T12:34:00Z
dc.date.available2019-07-05T12:34:00Z
dc.date.issued2019
dc.identifier.issn1431-6730
dc.identifier.doi10.1515/hsz-2018-0256
dc.identifier.urihttp://hdl.handle.net/10072/382425
dc.description.abstractMitochondria and oxidative phosphorylation (OXPHOS) are emerging as intriguing targets for the efficient elimination of cancer cells. The specificity of this approach is aided by the capacity of non-proliferating non-cancerous cells to withstand oxidative insult induced by OXPHOS inhibition. Recently we discovered that mitochondrial targeting can also be employed to eliminate senescent cells, where it breaks the interplay between OXPHOS and ATP transporters that appear important for the maintenance of mitochondrial morphology and viability in the senescent setting. Hence, mitochondria/OXPHOS directed pharmacological interventions show promise in several clinically-relevant scenarios that call for selective removal of cancer and senescent cells.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWalter de Gruyter
dc.publisher.placeGermany
dc.relation.ispartofpagefrom141
dc.relation.ispartofpageto148
dc.relation.ispartofissue2
dc.relation.ispartofjournalBiological Chemistry
dc.relation.ispartofvolume400
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode0601
dc.titleMitochondria-driven elimination of cancer and senescent cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Walter de Gruyter & Co. KG Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorRohlena, Jakub


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