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dc.contributor.authorSarna, Mohinder
dc.contributor.authorWare, Robert S
dc.contributor.authorLambert, Stephen B
dc.contributor.authorSloots, Theo P
dc.contributor.authorNissen, Michael D
dc.contributor.authorGrimwood, Keith
dc.date.accessioned2019-05-29T12:36:10Z
dc.date.available2019-05-29T12:36:10Z
dc.date.issued2018
dc.identifier.issn0022-1899
dc.identifier.doi10.1093/infdis/jix599
dc.identifier.urihttp://hdl.handle.net/10072/382449
dc.description.abstractBackground: Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. Methods: The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. Results: One hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was ≥13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%–83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. Conclusions: Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom418
dc.relation.ispartofpageto427
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume217
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310799
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode42
dc.titleTiming of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith
gro.griffith.authorWare, Robert


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