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dc.contributor.authorMarshall-Gradisnik, Sonya
dc.contributor.authorFretel, Marshall
dc.contributor.authorEaton, Natalie
dc.contributor.authorCabanas, Helene
dc.contributor.authorBalinas, Cassandra
dc.contributor.authorGopalan, Vinod
dc.contributor.authorPeterson, Daniel
dc.contributor.authorPassmore, Rachel
dc.contributor.authorHaque, Mazhar
dc.contributor.authorTang, Chee
dc.contributor.authorLam, Alfred
dc.contributor.authorStaines, Donald
dc.date.accessioned2019-05-29T12:42:24Z
dc.date.available2019-05-29T12:42:24Z
dc.date.issued2018
dc.identifier.issn2158-284X
dc.identifier.doi10.4236/ijcm.2018.95040
dc.identifier.urihttp://hdl.handle.net/10072/382452
dc.description.abstractIntroduction: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is often associated with gastrointestinal disturbance and inflammatory markers; however, there have been no histological studies performed in the small intestine from CFS/ME patients. The aim of this investigation was to assess the expression of certain inflammatory markers and inflammatory receptors, namely transient receptor potential melastin 3 (TRPM3) ion channels and muscarinic acetylcholine M3 (mAChRM3) receptors, in small intestinal tissues in a case controlled study comprising a CFS/ME patient and a healthy non-fatigued control. Method: Immunohistochemistry was performed on a small intestinal biopsy from a CFS/ME patient (age = 50; female) with self-reported symptoms of gastrointestinal disturbance and a non-fatigued control (NFC), (age = 28; female). Semi-quantitative analysis of expression was undertaken for interferon-gamma (IFNy), interleukin-1 alpha (IL-1α), tumour necrosis factor-alpha (TNFα), TRPM3 ion channels and mAChRM3 acetylcholine receptors. Results: There was significantly decreased expression of TRPM3 in the CFS/ME patient (35% ± 9%) and a significant decrease in mAChRM3 in the CFS/ME patient (54% ± 9%). There was no difference in IL-1α between CFS/ME patient and NFC, however; there was an increase in IFNy (13% ± 6%) in the CFS/ME patient compared to NFC. There was a difference observed in TNFα in CFS/ME compared to NFC. Conclusion: Differences were noted in the expression of specific TRP ion channels and cholinergic receptors in CFS/ME compared with NFC, with CFS/ME demonstrating decreased TRPM3 and mAChRM3. Further, IFNy was increased, and TNFα decreased, in the small intestine of the CFS/ME patient with reported gastrointestinal disturbance.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherScientific Research Publishing
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom467
dc.relation.ispartofpageto480
dc.relation.ispartofissue5
dc.relation.ispartofjournalInternational Journal of Clinical Medicine
dc.relation.ispartofvolume9
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode119999
dc.titleDecreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2018 The author(s) and SciRes. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorStaines, Don R.
gro.griffith.authorLam, Alfred K.
gro.griffith.authorGopalan, Vinod
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorPeterson, Daniel
gro.griffith.authorBalinas, Cassandra Z.
gro.griffith.authorPassmore, Rachel
gro.griffith.authorTang, Chee S.
gro.griffith.authorCabanas, Helene
gro.griffith.authorEaton-Fitch, Natalie R.


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