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dc.contributor.authorSenadeera, Sarath PD
dc.contributor.authorRobertson, Luke P
dc.contributor.authorDuffy, Sandra
dc.contributor.authorWang, Yun
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCarroll, Anthony R
dc.date.accessioned2019-06-12T12:33:22Z
dc.date.available2019-06-12T12:33:22Z
dc.date.issued2018
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.8b00494
dc.identifier.urihttp://hdl.handle.net/10072/382483
dc.description.abstractFour new β-triketone monoterpene hybrids, intermediones A–D (1–4), have been identified from the flowers of the Australian eucalypt tree Corymbia intermedia. Intermediones A–D are β-triketones that incorporate a pinene moiety attached via a benzyl group to a syncarpic acid. The structures of 1–4, including relative configurations, were elucidated from the analysis of 1D/2D NMR and MS data. The absolute configurations of intermediones A and B were determined by comparison of experimental and predicted ECD spectra. Intermedione D possesses a tetracyclic ring system that is related to that found in the meroterpenes, guadials B and C. Low to moderate antiplasmodial activity toward the chloroquine-sensitive (3D7) strain of Plasmodium falciparum, with IC50 values ranging from 9.9 to 20.8 μM, was observed for intermediones A, B, and D.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom2455
dc.relation.ispartofpageto2461
dc.relation.ispartofissue11
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume81
dc.subject.fieldofresearchChemical Sciences not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode039999
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode03
dc.titleβ-Triketone-Monoterpene Hybrids from the Flowers of the Australian Tree Corymbia intermedia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Environment and Science
gro.hasfulltextNo Full Text
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorWang, Yun
gro.griffith.authorRobertson, Luke P.
gro.griffith.authorSenadeera, Dayani


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