Show simple item record

dc.contributor.authorSenadeera, Sarath PD
dc.contributor.authorLucantoni, Leonardo
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCarroll, Anthony R
dc.date.accessioned2019-06-26T06:04:22Z
dc.date.available2019-06-26T06:04:22Z
dc.date.issued2018
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.8b00154
dc.identifier.urihttp://hdl.handle.net/10072/382486
dc.description.abstractThe methanol extract of the flowers of the Australian eucalypt tree Corymbia torelliana yielded six new β-triketone–flavanone hybrids, torellianones A–F (1–6), the tetrahydroxycyclohexane torellianol A (7), and known β-triketones (4S)-ficifolidione (8) and (4R)-ficifolidione (9), and β-triketone–flavanones kunzeanone A (10) and kunzeanone B (11). Torellianones A and B, C and D, and E and F were each isolated as inseparable diastereomeric mixtures. Exchange correlations observed in a ROESY spectrum indicated that 5 and 6 also interconverted between stable conformers. The structures of 1–7 were elucidated from the analysis of 1D/2D NMR and MS data. Relative configurations of torellianones C–F and torrellianol A were determined from analysis of ROESY data. Compounds 1–10 were tested for antiplasmodial activity against a drug-sensitive (3D7) strain of Plasmodium falciparum, with 3–6 and 8–10 showing limited antiplasmodial activity, with IC50 values ranging from 3.2 to 16.6 μM.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1588
dc.relation.ispartofpageto1597
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume81
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchOther chemical sciences not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode349999
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleAntiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Environment and Science
gro.hasfulltextNo Full Text
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record