dc.contributor.author | Senadeera, Sarath PD | |
dc.contributor.author | Lucantoni, Leonardo | |
dc.contributor.author | Duffy, Sandra | |
dc.contributor.author | Avery, Vicky M | |
dc.contributor.author | Carroll, Anthony R | |
dc.date.accessioned | 2019-06-26T06:04:22Z | |
dc.date.available | 2019-06-26T06:04:22Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/acs.jnatprod.8b00154 | |
dc.identifier.uri | http://hdl.handle.net/10072/382486 | |
dc.description.abstract | The methanol extract of the flowers of the Australian eucalypt tree Corymbia torelliana yielded six new β-triketone–flavanone hybrids, torellianones A–F (1–6), the tetrahydroxycyclohexane torellianol A (7), and known β-triketones (4S)-ficifolidione (8) and (4R)-ficifolidione (9), and β-triketone–flavanones kunzeanone A (10) and kunzeanone B (11). Torellianones A and B, C and D, and E and F were each isolated as inseparable diastereomeric mixtures. Exchange correlations observed in a ROESY spectrum indicated that 5 and 6 also interconverted between stable conformers. The structures of 1–7 were elucidated from the analysis of 1D/2D NMR and MS data. Relative configurations of torellianones C–F and torrellianol A were determined from analysis of ROESY data. Compounds 1–10 were tested for antiplasmodial activity against a drug-sensitive (3D7) strain of Plasmodium falciparum, with 3–6 and 8–10 showing limited antiplasmodial activity, with IC50 values ranging from 3.2 to 16.6 μM. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofpagefrom | 1588 | |
dc.relation.ispartofpageto | 1597 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 81 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Other chemical sciences not elsewhere classified | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 349999 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.title | Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Sciences, School of Environment and Science | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Carroll, Anthony R. | |
gro.griffith.author | Duffy, Sandra | |
gro.griffith.author | Avery, Vicky M. | |