Liquid Marble with Embedded Hydrogel: A Versatile Microbioreactor for Cell Biology Applications
Author(s)
Vadivelu, R
Kashaninejadand, N
Nguyen, NT
Year published
2018
Metadata
Show full item recordAbstract
We report a unique and robust bioreactor platform based on liquid marble (LM) with embedded hydrogel for digital microfluidics. The LM is a liquid droplet coated with hydrophobic powder. To prevent this droplet from evaporation, the LM floats on a liquid surface. Furthermore, a hydrogel loaded with growth factors and drugs is embedded in the LM. The hydrogel maintains the water content and concurrently acts as a slow-release carrier. This unique bioreactor platform allows for the use of liquid marble in various applications such as 3D cell culture, co-culture and cryopreservation.We report a unique and robust bioreactor platform based on liquid marble (LM) with embedded hydrogel for digital microfluidics. The LM is a liquid droplet coated with hydrophobic powder. To prevent this droplet from evaporation, the LM floats on a liquid surface. Furthermore, a hydrogel loaded with growth factors and drugs is embedded in the LM. The hydrogel maintains the water content and concurrently acts as a slow-release carrier. This unique bioreactor platform allows for the use of liquid marble in various applications such as 3D cell culture, co-culture and cryopreservation.
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Conference Title
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume
3
Publisher URI
Subject
Cell development, proliferation and death