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  • OPAL plus : Length-Specific MoRF Prediction in Intrinsically Disordered Protein Sequences

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    Author(s)
    Sharma, Ronesh
    Sharma, Alok
    Raicar, Gaurav
    Tsunoda, Tatsuhiko
    Patil, Ashwini
    Griffith University Author(s)
    Sharma, Alok
    Year published
    2019
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    Abstract
    Intrinsically disordered proteins (IDPs) contain long unstructured regions, which play an important role in their function. These intrinsically disordered regions (IDRs) participate in binding events through regions called molecular recognition features (MoRFs). Computational prediction of MoRFs helps identify the potentially functional regions in IDRs. In this study, OPAL+, a novel MoRF predictor, is presented. OPAL+ uses separate models to predict MoRFs of varying lengths along with incorporating the hidden Markov model (HMM) profiles and physicochemical properties of MoRFs and their flanking regions. Together, these ...
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    Intrinsically disordered proteins (IDPs) contain long unstructured regions, which play an important role in their function. These intrinsically disordered regions (IDRs) participate in binding events through regions called molecular recognition features (MoRFs). Computational prediction of MoRFs helps identify the potentially functional regions in IDRs. In this study, OPAL+, a novel MoRF predictor, is presented. OPAL+ uses separate models to predict MoRFs of varying lengths along with incorporating the hidden Markov model (HMM) profiles and physicochemical properties of MoRFs and their flanking regions. Together, these features help OPAL+ achieve a marginal performance improvement of 0.4–0.7% over its predecessor for diverse MoRF test sets. This performance improvement comes at the expense of increased run time as a result of the requirement of HMM profiles. OPAL+ is available for download at https://github.com/roneshsharma/OPAL-plus/wiki/OPAL-plus-Download.
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    Journal Title
    PROTEOMICS
    Volume
    19
    Issue
    6
    DOI
    https://doi.org/10.1002/pmic.201800058
    Copyright Statement
    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: OPAL+: Length‐Specific MoRF Prediction in Intrinsically Disordered Protein Sequences, Proteomics, Vol. 19, 1800058, pp. 1-4, 2019, which has been published in final form at 10.1002/pmic.201800058. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/382746
    Collection
    • Journal articles

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