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dc.contributor.authorPatist, Carla M
dc.contributor.authorStapelberg, Nicolas JC
dc.contributor.authorDu Toit, Eugene F
dc.contributor.authorHeadrick, John P
dc.date.accessioned2019-06-07T01:34:10Z
dc.date.available2019-06-07T01:34:10Z
dc.date.issued2018
dc.identifier.issn1530-7026
dc.identifier.doi10.3758/s13415-018-0626-0
dc.identifier.urihttp://hdl.handle.net/10072/382800
dc.description.abstractMajor depressive disorder (MDD) and obesity are dominant and inter-related health burdens. Obesity is a risk factor for MDD, and there is evidence MDD increases risk of obesity. However, description of a bidirectional relationship between obesity and MDD is misleading, as closer examination reveals distinct unidirectional relationships in MDD subtypes. MDD is frequently associated with weight loss, although obesity promotes MDD. In contrast, MDD with atypical features (MDD-AF) is characterised by subsequent weight gain and obesity. The bases of these distinct associations remain to be detailed, with conflicting findings clouding interpretation. These associations can be viewed within a systems biology framework—the psycho-immune neuroendocrine (PINE) network shared between MDD and metabolic disorders. Shared PINE subsystem perturbations may underlie increased MDD in overweight and obese people (obesity-associated depression), while obesity in MDD-AF (depression-associated obesity) involves more complex interactions between behavioural and biomolecular changes. In the former, the chronic PINE dysfunction triggering MDD is augmented by obesity-dependent dysregulation in shared networks, including inflammatory, leptin-ghrelin, neuroendocrine, and gut microbiome systems, influenced by chronic image-associated psychological stress (particularly in younger or female patients). In MDD-AF, behavioural dysregulation, including hypersensitivity to interpersonal rejection, fundamentally underpins energy imbalance (involving hyperphagia, lethargy, hypersomnia), with evolving obesity exaggerating these drivers via positive feedback (and potentially augmenting PINE disruption). In both settings, sex and age are important determinants of outcome, associated with differences in emotional versus cognitive dysregulation. A systems biology approach is recommended for further research into the pathophysiological networks underlying MDD and linking depression and obesity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofpagefrom1121
dc.relation.ispartofpageto1144
dc.relation.ispartofissue6
dc.relation.ispartofjournalCOGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
dc.relation.ispartofvolume18
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode5202
dc.titleThe brain-adipocyte-gut network: Linking obesity and depression subtypes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2018 Psychonomic Society, Inc. Published by Springer New York. This is an electronic version of an article published in Cognitive, Affective, & Behavioral Neuroscience, December 2018, Volume 18, Issue 6, pp 1121–1144. This document may not exactly correspond to the final published version. Psychonomic Society Publication disclaims any responsibility or liability for errors in this manuscript. The original publication is available at www.springerlink.com
gro.hasfulltextFull Text
gro.griffith.authorDu Toit, Eugene
gro.griffith.authorHeadrick, John P.


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