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  • Antithrombogenic peripherally inserted central catheters: overview of efficacy and safety

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    Rickard156612.pdf (338.8Kb)
    Author(s)
    Ullman, Amanda J
    Bulmer, AndreW C
    Dargaville, Tim R
    Rickard, Claire M
    Chopra, Vineet
    Griffith University Author(s)
    Bulmer, Andrew C.
    Dargaville, Tim
    Year published
    2019
    Metadata
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    Abstract
    Introduction: Thrombotic complications associated with peripherally inserted central catheters (PICCs) are common, as most synthetic materials when placed in the presence of serum often result in platelet activation, fibrin deposition, thrombotic occlusion, and potentially embolization. A current innovation focus has been the development of antithrombogenic catheter materials, including hydrophilic and hydrophobic surfaces. These are being incorporated into PICCs in an attempt to prevent the normal thrombotic cascade leading to patient harm. Areas covered: This review focuses on the laboratory efficacy and clinical effectiveness ...
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    Introduction: Thrombotic complications associated with peripherally inserted central catheters (PICCs) are common, as most synthetic materials when placed in the presence of serum often result in platelet activation, fibrin deposition, thrombotic occlusion, and potentially embolization. A current innovation focus has been the development of antithrombogenic catheter materials, including hydrophilic and hydrophobic surfaces. These are being incorporated into PICCs in an attempt to prevent the normal thrombotic cascade leading to patient harm. Areas covered: This review focuses on the laboratory efficacy and clinical effectiveness of antithrombogenic PICCs to prevent PICC-associated thrombosis, as well as their efficiency and safety. This synthesis was informed by a systematic identification of published and unpublished laboratory and clinical studies evaluating these technologies. Expert commentary: A range of PICCs have been developed with antithrombogenic claims, using varying technologies. However, to date, there is no peer-reviewed laboratory research describing the individual PICCs’ effectiveness. Despite promising early clinical trials, adequately powered trials to establish efficacy, effectiveness, efficiency, and safety of all of the individual products have not yet been undertaken.
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    Journal Title
    EXPERT REVIEW OF MEDICAL DEVICES
    Volume
    16
    Issue
    1
    DOI
    https://doi.org/10.1080/17434440.2019.1555466
    Copyright Statement
    © 2018 Expert Reviews Ltd. Published by Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Medical Devices on 2019, available online: https://doi.org/10.1080/17434440.2019.1555466
    Subject
    Biomedical engineering
    Central venous catheter thrombosis
    Deep vein thrombosis
    Peripheral venous catheterization
    Venous thromboembolism
    Publication URI
    http://hdl.handle.net/10072/382815
    Collection
    • Journal articles

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