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dc.contributor.authorComans, Tracy A
dc.contributor.authorKim-Huong, Nguyen
dc.contributor.authorMulhern, Brendan
dc.contributor.authorCorlis, Megan
dc.contributor.authorLi, Li
dc.contributor.authorWelch, Alyssa
dc.contributor.authorKurrle, Susan E
dc.contributor.authorRowen, Donna
dc.contributor.authorMoyle, Wendy
dc.contributor.authorKularatna, Sanjeewa
dc.contributor.authorRatcliffe, Julie
dc.date.accessioned2019-05-29T12:46:19Z
dc.date.available2019-05-29T12:46:19Z
dc.date.issued2018
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2017-018996
dc.identifier.urihttp://hdl.handle.net/10072/382920
dc.description.abstractIntroduction Generic instruments for assessing health-related quality of life may lack the sensitivity to detect changes in health specific to certain conditions, such as dementia. The Quality of Life in Alzheimer’s Disease (QOL-AD) is a widely used and well-validated condition-specific instrument for assessing health-related quality of life for people living with dementia, but it does not enable the calculation of quality-adjusted life years, the basis of cost utility analysis. This study will generate a preference-based scoring algorithm for a health state classification system -the Alzheimer’s Disease Five Dimensions (AD-5D) derived from the QOL-AD. Methods and analysis Discrete choice experiments with duration (DCETTO) and best–worst scaling health state valuation tasks will be administered to a representative sample of 2000 members of the Australian general population via an online survey and to 250 dementia dyads (250 people with dementia and their carers) via face-to-face interview. A multinomial (conditional) logistic framework will be used to analyse responses and produce the utility algorithm for the AD-5D. Ethics and dissemination The algorithms developed will enable prospective and retrospective economic evaluation of any treatment or intervention targeting people with dementia where the QOL-AD has been administered and will be available online. Results will be disseminated through journals that publish health economics articles and through professional conferences. This study has ethical approval
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMJ OPEN
dc.relation.ispartofvolume8
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.titleDeveloping a dementia-specific preference-based quality of life measure (AD-5D) in Australia: a valuation study protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionPublished
gro.rights.copyrightThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:// creativecommons. org/ licenses/ by- nc/ 4. 0/
gro.hasfulltextFull Text
gro.griffith.authorComans, Tracy
gro.griffith.authorMoyle, Wendy
gro.griffith.authorNguyen, Kim-Huong
gro.griffith.authorLi, Li


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