Synthetic Pathways to 3,4,5-Trihydroxypiperidines from the Chiral Pool
Author(s)
Wood, Adam
Prichard, Kate L
Clarke, Zane
Houston, Todd A
Fleet, George WJ
Simone, Michela I
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
3,4,5‐Trihydroxypiperidines represent a family of biologically active natural products, found to modulate principally the glycosidase enzymes. This is ascribed to their structural and electronic resemblance to the pyranose monosaccharides, their natural counterparts. Expedient syntheses are crucial to access these valuable high Fsp3 index drug leads. In this review we present the literature strategies to this class of iminosugars to spur further research into drug leads targeting the glycobiological machinery of living systems.3,4,5‐Trihydroxypiperidines represent a family of biologically active natural products, found to modulate principally the glycosidase enzymes. This is ascribed to their structural and electronic resemblance to the pyranose monosaccharides, their natural counterparts. Expedient syntheses are crucial to access these valuable high Fsp3 index drug leads. In this review we present the literature strategies to this class of iminosugars to spur further research into drug leads targeting the glycobiological machinery of living systems.
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Journal Title
European Journal of Organic Chemistry
Volume
2018
Issue
48
Subject
Medicinal and biomolecular chemistry
Organic chemistry