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dc.contributor.authorWood, Adam
dc.contributor.authorPrichard, Kate L
dc.contributor.authorClarke, Zane
dc.contributor.authorHouston, Todd A
dc.contributor.authorFleet, George WJ
dc.contributor.authorSimone, Michela I
dc.date.accessioned2019-07-31T06:03:03Z
dc.date.available2019-07-31T06:03:03Z
dc.date.issued2018
dc.identifier.issn1434-193X
dc.identifier.doi10.1002/ejoc.201800943
dc.identifier.urihttp://hdl.handle.net/10072/382923
dc.description.abstract3,4,5‐Trihydroxypiperidines represent a family of biologically active natural products, found to modulate principally the glycosidase enzymes. This is ascribed to their structural and electronic resemblance to the pyranose monosaccharides, their natural counterparts. Expedient syntheses are crucial to access these valuable high Fsp3 index drug leads. In this review we present the literature strategies to this class of iminosugars to spur further research into drug leads targeting the glycobiological machinery of living systems.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofpagefrom6812
dc.relation.ispartofpageto6829
dc.relation.ispartofissue48
dc.relation.ispartofjournalEuropean Journal of Organic Chemistry
dc.relation.ispartofvolume2018
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode0304
dc.titleSynthetic Pathways to 3,4,5-Trihydroxypiperidines from the Chiral Pool
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHouston, Todd A.


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