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dc.contributor.authorMcCarthy, AL
dc.contributor.authorPeel, NM
dc.contributor.authorGillespie, KM
dc.contributor.authorBerry, R
dc.contributor.authorWalpole, E
dc.contributor.authorYates, P
dc.contributor.authorHubbard, RE
dc.date.accessioned2019-05-29T12:46:51Z
dc.date.available2019-05-29T12:46:51Z
dc.date.issued2018
dc.identifier.issn1471-2407
dc.identifier.doi10.1186/s12885-018-4807-6
dc.identifier.urihttp://hdl.handle.net/10072/382966
dc.description.abstractBackground: Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and validate a frailty index (FI) from comprehensive geriatric assessment (CGA) data obtained in the solid tumour chemotherapy setting, and 2) to explore whether the FI-CGA could predict chemotherapy decisions and survival in older cancer patients with solid tumours. Methods: Prospective cohort study of a consecutive series sample of 175 cancer patients aged 65 and older with solid tumours. A frailty index was calculated using an accumulated deficits model, coding items from the comprehensive geriatric assessment tool administered prior to chemotherapy decision-making. The domains of physical and cognitive functioning, nutrition, mood, basic and instrumental activities of daily living, and comorbidities were incorporated as deficits into the model. Results: The FI-CGA had a right-skewed distribution, with median (interquartile range) of 0.27 (0.21-0.39). The 99% limit to deficit accumulation was below the theoretical maximum of 1.0, at 0.75. The FI-CGA was significantly related (p < 0.001) to vulnerability as assessed by the Vulnerable Elders Survey-13 and to medical oncologists' assessments of fitness or vulnerability to treatment. Baseline frailty as determined by the FI-CGA was also associated with treatment decisions (Treatment Terminated, Treatment Completed, No Planned Treatment) (p < 0.001), with the No Planned Treatment group significantly frailer than the other two groups. Conclusion: The FI-CGA is a potentially useful adjunct to cancer clinical decision-making that could predict chemotherapy outcomes in older patients with solid tumours.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Cancer
dc.relation.ispartofvolume18
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode4202
dc.titleValidation of a frailty index in older cancer patients with solid tumours 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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gro.griffith.authorMcCarthy, Sandie L.


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