dc.contributor.author | McCarthy, AL | |
dc.contributor.author | Peel, NM | |
dc.contributor.author | Gillespie, KM | |
dc.contributor.author | Berry, R | |
dc.contributor.author | Walpole, E | |
dc.contributor.author | Yates, P | |
dc.contributor.author | Hubbard, RE | |
dc.date.accessioned | 2019-05-29T12:46:51Z | |
dc.date.available | 2019-05-29T12:46:51Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1471-2407 | |
dc.identifier.doi | 10.1186/s12885-018-4807-6 | |
dc.identifier.uri | http://hdl.handle.net/10072/382966 | |
dc.description.abstract | Background: Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and validate a frailty index (FI) from comprehensive geriatric assessment (CGA) data obtained in the solid tumour chemotherapy setting, and 2) to explore whether the FI-CGA could predict chemotherapy decisions and survival in older cancer patients with solid tumours. Methods: Prospective cohort study of a consecutive series sample of 175 cancer patients aged 65 and older with solid tumours. A frailty index was calculated using an accumulated deficits model, coding items from the comprehensive geriatric assessment tool administered prior to chemotherapy decision-making. The domains of physical and cognitive functioning, nutrition, mood, basic and instrumental activities of daily living, and comorbidities were incorporated as deficits into the model. Results: The FI-CGA had a right-skewed distribution, with median (interquartile range) of 0.27 (0.21-0.39). The 99% limit to deficit accumulation was below the theoretical maximum of 1.0, at 0.75. The FI-CGA was significantly related (p < 0.001) to vulnerability as assessed by the Vulnerable Elders Survey-13 and to medical oncologists' assessments of fitness or vulnerability to treatment. Baseline frailty as determined by the FI-CGA was also associated with treatment decisions (Treatment Terminated, Treatment Completed, No Planned Treatment) (p < 0.001), with the No Planned Treatment group significantly frailer than the other two groups. Conclusion: The FI-CGA is a potentially useful adjunct to cancer clinical decision-making that could predict chemotherapy outcomes in older patients with solid tumours. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BMC | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | BMC Cancer | |
dc.relation.ispartofvolume | 18 | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearch | Epidemiology | |
dc.subject.fieldofresearchcode | 3211 | |
dc.subject.fieldofresearchcode | 4202 | |
dc.title | Validation of a frailty index in older cancer patients with solid tumours 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | McCarthy, Sandie L. | |