dc.contributor.author | Takashima, Mari | |
dc.contributor.author | Lambert, Stephen B | |
dc.contributor.author | Paynter, Stuart | |
dc.contributor.author | Ware, Robert S | |
dc.date.accessioned | 2019-05-29T12:47:05Z | |
dc.date.available | 2019-05-29T12:47:05Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0264-410X | |
dc.identifier.doi | 10.1016/j.vaccine.2019.01.085 | |
dc.identifier.uri | http://hdl.handle.net/10072/382994 | |
dc.description.abstract | Background:
Aboriginal and Torres Strait Islander (Indigenous) Australians have high rates of invasive pneumococcal disease (IPD), with repeat doses of 23-valent polysaccharide pneumococcal vaccine (PPV23) recommended. We report the relative effectiveness of revaccination using a cohort from linked administrative data.
Methods:
All resident North Queensland Indigenous adults who received any PPV23 vaccination between 2000 and 2012 were identified and linked with IPD cases. IPD rates were compared for individuals revaccinated >five years after initial PPV23 dose against individuals not revaccinated.
Results:
Analysed data included 12,809 individuals and 89,612 person-years. Revaccinated adults had similar rates of IPD as non-revaccinated adults, after adjusting for potential confounders (HR = 0.92; 95%CI: 0.35–2.42). Findings were similar for vaccine-specific serotypes (HR = 1.32; 95%CI: 0.32–5.43).
Conclusions:
Benefits of PPV23 revaccination against IPD in this high-risk population were not demonstrated, although estimates were imprecise. Findings should be validated in other high-risk cohorts, and against all-cause pneumonia as an outcome. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science | |
dc.relation.ispartofpagefrom | 1638 | |
dc.relation.ispartofpageto | 1641 | |
dc.relation.ispartofissue | 12 | |
dc.relation.ispartofjournal | VACCINE | |
dc.relation.ispartofvolume | 37 | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Relative effectiveness of revaccination with 23-valent pneumococcal polysaccharide vaccine in preventing invasive pneumococcal disease in adult Aboriginal and Torres Strait Islander people, Australia | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Ware, Robert | |