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dc.contributor.authorTakashima, Mari
dc.contributor.authorLambert, Stephen B
dc.contributor.authorPaynter, Stuart
dc.contributor.authorWare, Robert S
dc.date.accessioned2019-05-29T12:47:05Z
dc.date.available2019-05-29T12:47:05Z
dc.date.issued2019
dc.identifier.issn0264-410X
dc.identifier.doi10.1016/j.vaccine.2019.01.085
dc.identifier.urihttp://hdl.handle.net/10072/382994
dc.description.abstractBackground: Aboriginal and Torres Strait Islander (Indigenous) Australians have high rates of invasive pneumococcal disease (IPD), with repeat doses of 23-valent polysaccharide pneumococcal vaccine (PPV23) recommended. We report the relative effectiveness of revaccination using a cohort from linked administrative data. Methods: All resident North Queensland Indigenous adults who received any PPV23 vaccination between 2000 and 2012 were identified and linked with IPD cases. IPD rates were compared for individuals revaccinated >five years after initial PPV23 dose against individuals not revaccinated. Results: Analysed data included 12,809 individuals and 89,612 person-years. Revaccinated adults had similar rates of IPD as non-revaccinated adults, after adjusting for potential confounders (HR = 0.92; 95%CI: 0.35–2.42). Findings were similar for vaccine-specific serotypes (HR = 1.32; 95%CI: 0.32–5.43). Conclusions: Benefits of PPV23 revaccination against IPD in this high-risk population were not demonstrated, although estimates were imprecise. Findings should be validated in other high-risk cohorts, and against all-cause pneumonia as an outcome.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofpagefrom1638
dc.relation.ispartofpageto1641
dc.relation.ispartofissue12
dc.relation.ispartofjournalVACCINE
dc.relation.ispartofvolume37
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleRelative effectiveness of revaccination with 23-valent pneumococcal polysaccharide vaccine in preventing invasive pneumococcal disease in adult Aboriginal and Torres Strait Islander people, Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLambert, Stephen B.
gro.griffith.authorTakashima, Mari
gro.griffith.authorWare, Robert


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