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  • "Mind your Moles' study: protocol of a prospective cohort study of melanocytic naevi

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    Author(s)
    Koh, Uyen
    Janda, Monika
    Aitken, Joanne F
    Duffy, David L
    Menzies, Scott
    Sturm, Richard A
    Schaider, Helmut
    Betz-Stablein, Brigid
    Prow, Tarl
    Soyer, H Peter
    Green, Adele C
    Griffith University Author(s)
    Aitken, Joanne
    Year published
    2018
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    Abstract
    Introduction: Having many melanocytic naevi or ‘moles’ on the skin is the strongest predictor of melanoma; thus, much can be learnt from investigating naevi in the general population. We aim to improve the understanding of the epidemiology and biology of naevi by conducting a 3-year prospective study of melanocytic naevi in adults. Methods and analysis: This is a population-based cohort study of melanocytic naevi in 200 adults aged 20–69 years recruited via the Australian electoral roll. At baseline, participants will complete a questionnaire on their sun behaviour and health and undergo a clinical examination. Three-dimensional ...
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    Introduction: Having many melanocytic naevi or ‘moles’ on the skin is the strongest predictor of melanoma; thus, much can be learnt from investigating naevi in the general population. We aim to improve the understanding of the epidemiology and biology of naevi by conducting a 3-year prospective study of melanocytic naevi in adults. Methods and analysis: This is a population-based cohort study of melanocytic naevi in 200 adults aged 20–69 years recruited via the Australian electoral roll. At baseline, participants will complete a questionnaire on their sun behaviour and health and undergo a clinical examination. Three-dimensional (3D) total-body photography will be used to record the images of skin lesions. Pigmented naevi will be analysed in terms of number, diameter, colour and border irregularity using automated analysis software (excluding scalp, beneath underwear and soles of feet). All naevi ≥5 mm will be recorded using the integrated dermoscopy photographic system. A saliva sample will be obtained at baseline for genomic DNA analysis of pigmentation, naevus and melanoma-associated genes using the Illumina HumanCoreExome platform. The sun behaviour and health follow-up questionnaire, clinical examination and 3D total-body photography will be repeated every 6 months for 3 years. The first 50 participants will also undergo manual counts of naevi ≥2 mm and ≥5 mm at baseline, 6-month and 12-month follow-ups. Microbiopsy and excision of naevi of research interest is planned to commence at the 18-month time point among those who agree to donate samples for detailed histopathological and molecular assessment.
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    Journal Title
    BMJ OPEN
    Volume
    8
    Issue
    9
    DOI
    https://doi.org/10.1136/bmjopen-2018-025857
    Copyright Statement
    © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Other health sciences
    Publication URI
    http://hdl.handle.net/10072/383009
    Collection
    • Journal articles

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