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  • A rapid, maskless 3D prototyping for fabrication of capillary circuits: Toward urinary protein detection

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    Accepted Manuscript (AM)
    Author(s)
    Yan, Sheng
    Zhu, Yuanqing
    Tang, Shi-Yang
    Li, Yuxing
    Zhao, Qianbin
    Yuan, Dan
    Yun, Guolin
    Zhang, Jun
    Zhang, Shiwu
    Li, Weihua
    Griffith University Author(s)
    Zhang, Jun
    Year published
    2018
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    Abstract
    Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point‐of‐care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser engraving. The capillary circuits can be fabricated in a short amount of time (<10 min) without the requirements of clean‐room facilities and photomasks. The advanced capillary components (e.g., trigger ...
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    Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point‐of‐care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser engraving. The capillary circuits can be fabricated in a short amount of time (<10 min) without the requirements of clean‐room facilities and photomasks. The advanced capillary components (e.g., trigger valves, retention valves and retention bursting valves) were fabricated, enabling the sequential liquid delivery and sample‐reagent mixing. With the integration of smartphone‐based detection platform, the microfluidic device can quantify the urinary protein via a colorimetric analysis. By eliminating the bulky and expensive equipment, this smartphone‐based detection platform is portable for on‐site quantitative detection.
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    Journal Title
    ELECTROPHORESIS
    Volume
    39
    Issue
    7
    DOI
    https://doi.org/10.1002/elps.201700449
    Copyright Statement
    © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: A rapid, maskless 3D prototyping for fabrication of capillary circuits: Toward urinary protein detection, Electrophoresis, Volume39, Issue7, April 2018, which has been published in final form at https://doi.org/10.1002/elps.201700449. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Analytical chemistry
    Biochemistry and cell biology
    Chemical engineering
    Publication URI
    http://hdl.handle.net/10072/383119
    Collection
    • Journal articles

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