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dc.contributor.authorMangwiro, Yeukai TM
dc.contributor.authorBriffa, Jessica F
dc.contributor.authorGravina, Sogand
dc.contributor.authorMahizir, Dayana
dc.contributor.authorAnevska, Kristina
dc.contributor.authorRomano, Tania
dc.contributor.authorMoritz, Karen M
dc.contributor.authorCuffe, James SM
dc.contributor.authorWlodek, Mary E
dc.date.accessioned2019-06-06T01:35:39Z
dc.date.available2019-06-06T01:35:39Z
dc.date.issued2018
dc.identifier.issn0143-4004
dc.identifier.doi10.1016/j.placenta.2018.12.005
dc.identifier.urihttp://hdl.handle.net/10072/383131
dc.description.abstractFetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of nutrient exchange, which is regulated by vasculogenic and angiogenic factors. These factors are altered by intrauterine growth restriction (IUGR) and maternal obesity in both the first (F1) and second (F2) generations. We investigated the impact of endurance exercise in IUGR dams fed a High-fat diet on placental vasculogenesis and angiogenesis. Uteroplacental insufficiency (Restricted) or sham (Control) surgery was induced on embryonic day (E) 18 in Wistar-Kyoto rats. F1 offspring were fed a Chow or High-fat diet from weaning, and at 16 weeks were further allocated an exercise protocol; Sedentary, Exercised prior to and during pregnancy (Exercise), or Exercised during pregnancy only (PregEx). Females were mated (20 weeks) and F2 placentae collected at E20. Maternal Restriction, High-fat feeding and Exercise had a minimal impact on placental regulators of vasculogenesis and angiogenesis. However, Restriction increased placental labyrinth tissue area in Chow-fed dams. PregEx induced overt adaptations, including increased VEGFA and decreased PLGF protein expression, and reduced blood space area. These alterations were sex-dependent and associated with alterations in miRNA27a, a known regulator of VEGF translation. These data highlight that maternal exercise initiated during pregnancy (PregEx) causes alterations in placental vasculogenesis and angiogenesis in a sex-dependent manner, with minimal Restriction and maternal diet effects. However, further investigation is required to determine if these adaptations are beneficial or harmful for maternal and fetoplacental outcomes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom47
dc.relation.ispartofpageto54
dc.relation.ispartofjournalPlacenta
dc.relation.ispartofvolume74
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3202
dc.titleMaternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCuffe, James S.


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