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dc.contributor.authorAtabila, Albert
dc.contributor.authorPhung, Dung Tri
dc.contributor.authorSadler, Ross
dc.contributor.authorConnell, Des
dc.contributor.authorChu, Cordia
dc.date.accessioned2019-06-08T01:33:16Z
dc.date.available2019-06-08T01:33:16Z
dc.date.issued2019
dc.identifier.issn0147-6513
dc.identifier.doi10.1016/j.ecoenv.2019.01.077
dc.identifier.urihttp://hdl.handle.net/10072/383248
dc.description.abstractChlorpyrifos is one of the most widely used organophosphate pesticides and has a record of adverse effects on applicators. Assessment of exposure to chlorpyrifos based on its urinary metabolite, 3,5,6-trichloro-2-pyridinol (TCP), is considered as the most accurate. However, urine sampling can be difficult, and the laboratory analytical procedures involved are complex and expensive. A simpler approach for assessing pesticide exposure among applicators is the whole-body dermal dosimetry method, but this needs validation. The objective of this study was to compare chlorpyrifos exposure estimates obtained separately with the urinary TCP and the whole-body dermal dosimetry methods from applicators. Exposure estimates from the whole-body dermal dosimetry method (5–29 μg/kg/day) showed less variation than those from the urinary TCP method (1–71 μg/kg/day), but both were in close agreement at the mean level (16 μg/kg/day and 15 μg/kg/day, respectively). The whole-body dermal dosimetry method is therefore valid for providing estimates of the typical levels of pesticide exposure among applicators in situations where the urinary TCP method cannot be applied.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofpagefrom439
dc.relation.ispartofpageto443
dc.relation.ispartofjournalECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
dc.relation.ispartofvolume172
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEnvironmental Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode05
dc.subject.fieldofresearchcode11
dc.titleComparative evaluation of chlorpyrifos exposure estimates from whole-body dermal dosimetry and urinary trichloro-2-pyridinol (TCP) methods
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
gro.rights.copyright© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorPhung, Dung T.
gro.griffith.authorConnell, Des W.
gro.griffith.authorChu, Cordia M.
gro.griffith.authorSadler, Ross F.


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