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dc.contributor.authorSmith, Joshua R
dc.contributor.authorCross, Troy J
dc.contributor.authorVan Iterson, Erik H
dc.contributor.authorJohnson, Bruce D
dc.contributor.authorOlson, Thomas P
dc.date.accessioned2019-06-26T06:01:34Z
dc.date.available2019-06-26T06:01:34Z
dc.date.issued2018
dc.identifier.issn8750-7587
dc.identifier.doi10.1152/japplphysiol.01105.2017
dc.identifier.urihttp://hdl.handle.net/10072/383255
dc.description.abstractIt is unknown whether the greater total work of breathing (WOB) with aging is due to greater elastic and/or resistive WOB. We hypothesized that older compared with younger adults would exhibit a greater total WOB at matched ventilations (V̇e) during graded exercise, secondary to greater inspiratory resistive and elastic as well as expiratory resistive WOB. Older (OA: 60 ± 8 yr; n = 9) and younger (YA: 38 ± 7 yr; n = 9) adults performed an incremental cycling test to volitional fatigue. Esophageal pressure, inspiratory (IRV) and expiratory reserve volumes (ERV), expiratory flow limitation (EFL), and ventilatory variables were measured at matched V̇e (i.e., 25, 50, and 75 l/min) during exercise. The inspiratory resistive and elastic as well as expiratory resistive WOB were quantified using the Otis method. At V̇e of 75 l/min, older adults had greater %EFL and larger tidal volumes to inspiratory capacity but smaller relative IRV (P ≤ 0.03) than younger adults. Older compared with younger adults had greater total WOB at V̇E of 50 and 75 l/min (OA: 90 ± 43 vs. YA: 49 ± 21 J/min; P < 0.04 for both). At V̇e of 75 l/min, older adults had greater inspiratory elastic and resistive WOB (OA: 44 ± 27 vs. YA: 24 ± 22 and OA: 23 ± 15 vs. YA: 11 ± 3 J/min, respectively, P < 0.03 for both) and expiratory resistive WOB (OA: 23 ± 19 vs. YA: 14 ± 9 J/min, P = 0.02) than younger adults. These data demonstrate that aging-induced pulmonary alterations result in greater inspiratory elastic and resistive as well as expiratory resistive WOB, which may have implications for the integrated response during exercise.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAMER PHYSIOLOGICAL SOC
dc.relation.ispartofpagefrom190
dc.relation.ispartofpageto197
dc.relation.ispartofissue1
dc.relation.ispartofjournalJOURNAL OF APPLIED PHYSIOLOGY
dc.relation.ispartofvolume125
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleResistive and elastic work of breathing in older and younger adults during exercise
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCross, Troy J.


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