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dc.contributor.authorMangwiro, Yeukai TM
dc.contributor.authorCuffe, James SM
dc.contributor.authorBriffa, Jessica F
dc.contributor.authorMahizir, Dayana
dc.contributor.authorAnevska, Kristina
dc.contributor.authorJefferies, Andrew J
dc.contributor.authorHosseini, Sogand
dc.contributor.authorRomano, Tania
dc.contributor.authorMoritz, Karen M
dc.contributor.authorWlodek, Mary E
dc.date.accessioned2019-06-19T13:05:19Z
dc.date.available2019-06-19T13:05:19Z
dc.date.issued2018
dc.identifier.issn0022-3751
dc.identifier.doi10.1113/JP275758
dc.identifier.urihttp://hdl.handle.net/10072/383352
dc.description.abstractThe insulin‐like growth factor (IGF) system regulates fetoplacental growth and plays a role in disease programming. Dysregulation of the IGF system is implicated in several pregnancy perturbations associated with altered fetal growth, including intrauterine growth restriction and maternal obesity. Limited human studies have demonstrated that maternal exercise enhances fetoplacental growth and decreases cord IGF ligands, which may restore the placental IGF system in complicated pregnancies. This study investigated the impact maternal exercise has on the placental IGF system in placentae from mothers born growth restricted and if these outcomes are dependent on maternal diet or fetal sex. Uteroplacental insufficiency (Restricted) or sham (Control) surgery was induced on embryonic day (E) 18 in Wistar–Kyoto rats. F1 offspring were fed a chow or high‐fat diet from weaning, and at 16 weeks were randomly allocated an exercise protocol: Sedentary, Exercised prior to and during pregnancy (Exercise), or Exercised during pregnancy only (PregEx). Females were mated (20 weeks) with placentae associated with F2 fetuses collected at E20. The placental IGF system mRNA abundance and placental morphology was altered in mothers born growth restricted. Exercise increased fetal weight and Control plasma IGF1 concentrations, and decreased female placental weight. PregEx did not influence fetoplacental growth but increased placental IGF1 and IGF1R (potentially modulated by reduced Let 7f‐1 miRNA) and decreased placental IGF2 protein. Importantly, these placental IGF system changes occurred with sex‐specific responses. These data highlight that exercise differently influences fetoplacental growth and the placental IGF system depending on maternal exercise initiation, which may prevent the transgenerational transmission of deficits and dysfunction.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofpagefrom5947
dc.relation.ispartofpageto5964
dc.relation.ispartofissue23
dc.relation.ispartofjournalJOURNAL OF PHYSIOLOGY-LONDON
dc.relation.ispartofvolume596
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleMaternal exercise in rats upregulates the placental insulin-like growth factor system with diet- and sex-specific responses: minimal effects in mothers born growth restricted
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCuffe, James S.


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