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  • The devil is in the details: Genomics of transmissible cancers in Tasmanian devils

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    MCCALLUM171224.pdf (2.358Mb)
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    Author(s)
    Storfer, Andrew
    Hohenlohe, Paul A
    Margres, Mark J
    Patton, Austin
    Fraik, Alexandra K
    Lawrance, Matthew
    Ricci, Lauren E
    Stahlke, Amanda R
    McCallum, Hamish I
    Jones, Menna E
    Griffith University Author(s)
    McCallum, Hamish
    Year published
    2018
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    Abstract
    Cancer poses one of the greatest human health threats of our time. Fortunately, aside from a few rare cases of cancer transmission in immune-suppressed organ transplant recipients [1] or a small number of transmission events from mother to fetus [2], cancers are not spread from human to human. However, transmissible cancers have been detected in vertebrate and invertebrate animals, sometimes with devastating effects [3]. Four examples of transmissible cancers are now known: 1) canine transmissible venereal tumor (CTVT) in dogs [4], 2) a tumor in a laboratory population of Syrian hamsters that is no longer cultured [3], 3) ...
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    Cancer poses one of the greatest human health threats of our time. Fortunately, aside from a few rare cases of cancer transmission in immune-suppressed organ transplant recipients [1] or a small number of transmission events from mother to fetus [2], cancers are not spread from human to human. However, transmissible cancers have been detected in vertebrate and invertebrate animals, sometimes with devastating effects [3]. Four examples of transmissible cancers are now known: 1) canine transmissible venereal tumor (CTVT) in dogs [4], 2) a tumor in a laboratory population of Syrian hamsters that is no longer cultured [3], 3) infectious neoplasias in at least four species of bivalve mollusks [5,6], and 4) two independently derived transmissible cancers (devil facial tumor disease [DFTD]) in Tasmanian devils [7–10] (Fig 1A and 1B). The etiologic agents of CTVT [4], the bivalve cancers [5], and DFTD [7] are the transplants (allografts) of the neoplastic cells themselves, but the etiologic agent is unknown for the hamster tumor.
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    Journal Title
    PLOS PATHOGENS
    Volume
    14
    Issue
    8
    DOI
    https://doi.org/10.1371/journal.ppat.1007098
    Copyright Statement
    © 2018 McCallum, et. al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Subject
    Microbiology
    Immunology
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/383450
    Collection
    • Journal articles

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