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  • Blood-device interaction

    Author(s)
    Simmonds, Michael J
    Watanabe, Nobuo
    Nandakumar, Deepika
    Horobin, Jarod
    Griffith University Author(s)
    Simmonds, Michael J.
    Horobin, Jarod T.
    Year published
    2018
    Metadata
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    Abstract
    Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination ...
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    Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination therapies, with a resultant increase in clinical utilization. It is clear, however, that while mechanical circulatory and respiratory support devices can sustain life, damage to blood and its constituents, and/or activation of cellular processes, can negatively impact recovery and health. These adverse effects may be broadly related to blood exposure to high shear stress and/or interactions between biological and artificial materials. Only through advances in mechanical circulatory and respiratory support to minimize blood damage will complications be overcome and mechanical devices attain their true potential.
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    Book Title
    MECHANICAL CIRCULATORY AND RESPIRATORY SUPPORT
    DOI
    https://doi.org/10.1016/B978-0-12-810491-0.00019-9
    Subject
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/383540
    Collection
    • Book chapters

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