Blood-device interaction
Author(s)
Simmonds, Michael J
Watanabe, Nobuo
Nandakumar, Deepika
Horobin, Jarod
Year published
2018
Metadata
Show full item recordAbstract
Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination ...
View more >Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination therapies, with a resultant increase in clinical utilization. It is clear, however, that while mechanical circulatory and respiratory support devices can sustain life, damage to blood and its constituents, and/or activation of cellular processes, can negatively impact recovery and health. These adverse effects may be broadly related to blood exposure to high shear stress and/or interactions between biological and artificial materials. Only through advances in mechanical circulatory and respiratory support to minimize blood damage will complications be overcome and mechanical devices attain their true potential.
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View more >Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination therapies, with a resultant increase in clinical utilization. It is clear, however, that while mechanical circulatory and respiratory support devices can sustain life, damage to blood and its constituents, and/or activation of cellular processes, can negatively impact recovery and health. These adverse effects may be broadly related to blood exposure to high shear stress and/or interactions between biological and artificial materials. Only through advances in mechanical circulatory and respiratory support to minimize blood damage will complications be overcome and mechanical devices attain their true potential.
View less >
Book Title
MECHANICAL CIRCULATORY AND RESPIRATORY SUPPORT
Subject
Biomedical and clinical sciences