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dc.contributor.authorSimmonds, Michael J
dc.contributor.authorWatanabe, Nobuo
dc.contributor.authorNandakumar, Deepika
dc.contributor.authorHorobin, Jarod
dc.contributor.editorGregory, SD
dc.contributor.editorStevens, MC
dc.contributor.editorFraser, JF
dc.date.accessioned2019-06-09T01:34:17Z
dc.date.available2019-06-09T01:34:17Z
dc.date.issued2018
dc.identifier.isbn978-0-12-810491-0
dc.identifier.doi10.1016/B978-0-12-810491-0.00019-9
dc.identifier.urihttp://hdl.handle.net/10072/383540
dc.description.abstractManagement of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from “bridge” therapies toward destination therapies, with a resultant increase in clinical utilization. It is clear, however, that while mechanical circulatory and respiratory support devices can sustain life, damage to blood and its constituents, and/or activation of cellular processes, can negatively impact recovery and health. These adverse effects may be broadly related to blood exposure to high shear stress and/or interactions between biological and artificial materials. Only through advances in mechanical circulatory and respiratory support to minimize blood damage will complications be overcome and mechanical devices attain their true potential.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
dc.relation.ispartofbooktitleMECHANICAL CIRCULATORY AND RESPIRATORY SUPPORT
dc.relation.ispartofchapter19
dc.relation.ispartofpagefrom597
dc.relation.ispartofpageto626
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode11
dc.titleBlood-device interaction
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorSimmonds, Michael J.
gro.griffith.authorHorobin, Jarod T.


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