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dc.contributor.authorFoong, Y.en_US
dc.contributor.authorJans, D.en_US
dc.contributor.authorRolph, M.en_US
dc.contributor.authorGahan, M.en_US
dc.contributor.authorMahalingam, S.en_US
dc.date.accessioned2017-04-24T13:32:17Z
dc.date.available2017-04-24T13:32:17Z
dc.date.issued2009en_US
dc.date.modified2011-04-27T06:57:58Z
dc.identifier.issn00426822en_US
dc.identifier.doi10.1016/j.virol.2009.07.030en_AU
dc.identifier.urihttp://hdl.handle.net/10072/38354
dc.description.abstractInterleukin-15 (IL-15) is a potent growth factor for activated T and natural killer (NK) cells, stimulator of memory T cells and plays an important role in viral immunity. To investigate mechanisms underlying the antiviral activity of IL-15, a recombinant vaccinia virus (rVV) encoding murine IL-15 (VV-IL-15) was constructed. Following infection of mice with VV-IL-15, virus titres in the ovaries were significantly reduced compared to mice infected with control VV. Growth of VV-IL-15 was also reduced in nude athymic mice, indicating the antiviral activity of IL-15 does not require T cells. Additionally, VV-IL-15 augmented the cytolytic activity of natural NK cells in the spleen and enhanced interferon (IFN) mRNA expression and transcription factors associated with IFN induction. Using knockout mice and antibody depletion studies, we showed for the first time that the control of VV-IL-15 replication in mice is dependent on NK cells and IFNs and, in their absence, the protective role of IL-15 is abolished.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom228en_US
dc.relation.ispartofpageto237en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalVirologyen_US
dc.relation.ispartofvolume393en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchVirologyen_US
dc.subject.fieldofresearchCellular Immunologyen_US
dc.subject.fieldofresearchcode060506en_US
dc.subject.fieldofresearchcode110704en_US
dc.titleInterleukin-15 mediates potent antiviral responses via an interferon-dependent mechanismen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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