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dc.contributor.authorMatejcic, Marco
dc.contributor.authorSaunders, Edward J
dc.contributor.authorDadaev, Tokhir
dc.contributor.authorBrook, Mark N
dc.contributor.authorWang, Kan
dc.contributor.authorSheng, Xin
dc.contributor.authorAl Olama, Ali Amin
dc.contributor.authorSchumacher, Fredrick R
dc.contributor.authorIngles, Sue A
dc.contributor.authorGovindasami, Koveela
dc.contributor.authorBenlloch, Sara
dc.contributor.authorBerndt, Sonja
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorKoutros, Stella
dc.contributor.authorMuir, Kenneth
dc.contributor.authorStevens, Victoria L
dc.contributor.authorGapstur, Susan M
dc.contributor.authorTangen, Catherine M
dc.contributor.authorBatra, Jyotsna
dc.contributor.authorClements, Judith
dc.contributor.authorGronberg, Henrik
dc.contributor.authorPashayan, Nora
dc.contributor.authorSchleutker, Johanna
dc.contributor.authorWolk, Alicja
dc.contributor.authorWest, Catharine
dc.contributor.authorMucci, Lorelei
dc.contributor.authorKraft, Peter
dc.contributor.authorCancel-Tassin, Geraldine
dc.contributor.authorSorensen, Karina D
dc.contributor.authorMaehle, Lovise
dc.contributor.authorGrindedal, Eli M
dc.contributor.authorStrom, Sara S
dc.contributor.authorNeal, David E
dc.contributor.authorHamdy, Freddie C
dc.contributor.authorDonovan, Jenny L
dc.contributor.authorTravis, Ruth C
dc.contributor.authorHamilton, Robert J
dc.contributor.authorRosenstein, Barry
dc.contributor.authorLu, Yong-Jie
dc.contributor.authorGiles, Graham G
dc.contributor.authorKibel, Adam S
dc.contributor.authorVega, Ana
dc.contributor.authorBensen, Jeanette T
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPenney, Kathryn L
dc.contributor.authorPark, Jong Y
dc.contributor.authorStanford, Janet L
dc.contributor.authorCybulski, Cezary
dc.contributor.authorNordestgaard, Borge G
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMaier, Christiane
dc.contributor.authorKim, Jeri
dc.contributor.authorTeixeira, Manuel R
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorDe Ruyck, Kim
dc.contributor.authorRazack, Azad
dc.contributor.authorNewcomb, Lisa F
dc.contributor.authorLessel, Davor
dc.contributor.authorKaneva, Radka
dc.contributor.authorUsmani, Nawaid
dc.contributor.authorClaessens, Frank
dc.contributor.authorTownsend, Paul A
dc.contributor.authorDominguez, Manuela G
dc.contributor.authorRoobol, Monique J
dc.contributor.authorMenegaux, Florence
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorCannon-Albright, Lisa A
dc.contributor.authorPandha, Hardev
dc.contributor.authorThibodeau, Stephen N
dc.contributor.authorSchaid, Daniel J
dc.contributor.authorWiklund, Fredrik
dc.contributor.authorChanock, Stephen J
dc.contributor.authorEaston, Douglas F
dc.contributor.authorEeles, Rosalind A
dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorConti, David
dc.contributor.authorHaiman, Christopher A
dc.date.accessioned2019-07-05T12:31:55Z
dc.date.available2019-07-05T12:31:55Z
dc.date.issued2018
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/s41467-018-06863-1
dc.identifier.urihttp://hdl.handle.net/10072/383594
dc.description.abstractChromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10 −15 ), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofissue1
dc.relation.ispartofjournalNATURE COMMUNICATIONS
dc.relation.ispartofvolume9
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.titleGermline variation at 8q24 and prostate cancer risk in men of European ancestry
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyrightThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
gro.hasfulltextFull Text
gro.griffith.authorChambers, Suzanne K.
gro.griffith.authorAitken, Joanne


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