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dc.contributor.authorNawaratna, Sujeevi SK
dc.contributor.authorYou, Hong
dc.contributor.authorJones, Malcolm K
dc.contributor.authorMcManus, Donald P
dc.contributor.authorGobert, Geoffrey N
dc.date.accessioned2019-08-12T00:48:19Z
dc.date.available2019-08-12T00:48:19Z
dc.date.issued2018
dc.identifier.issn0300-5127
dc.identifier.doi10.1042/BST20180480
dc.identifier.urihttp://hdl.handle.net/10072/383654
dc.description.abstractIn eukaryotes, effective calcium homeostasis is critical for many key biological processes. There is an added level of complexity in parasites, particularly multicellular helminth worms, which modulate calcium levels while inhabiting the host microenvironment. Parasites ensure efficient calcium homeostasis through gene products, such as the calmodulin-dependent kinases (CaMK), the main focus of this review. The importance of CaMK is becoming increasingly apparent from recent functional studies of helminth and protozoan parasites. Investigations on the molecular regulation of calcium and the role of CaMK are important for both supplementing current drug regimens and finding new antiparasitic compounds. Whereas calcium regulators, including CaMK, are well characterised in mammalian systems, knowledge of their functional properties in parasites is increasing but is still in its infancy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPortland Press
dc.relation.ispartoflocationEngland
dc.relation.ispartofpagefrom1743
dc.relation.ispartofpageto1751
dc.relation.ispartofissue6
dc.relation.ispartofjournalBiochem Soc Trans
dc.relation.ispartofvolume46
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.titleCalcium and Ca2+/Calmodulin-dependent kinase II as targets for helminth parasite control.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNawaratna, Sujeevi S.


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