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dc.contributor.authorFreitas, Joseph R
dc.contributor.authorRao, Shambhavi
dc.contributor.authorMahalingam, Suresh
dc.date.accessioned2019-08-08T03:18:08Z
dc.date.available2019-08-08T03:18:08Z
dc.date.issued2018
dc.identifier.issn1324-4272
dc.identifier.doi10.1071/MA18021
dc.identifier.urihttp://hdl.handle.net/10072/383687
dc.description.abstractThe natural progression of chikungunya virus (CHIKV) disease can consist of three stages – acute, post-acute and chronic, each having different clinical features. The acute phase (up to 3 weeks) is characterised by high viremia, fever, rash, polyarthralgia, synovitis and intense inflammation. Complete recovery is achieved in most symptomatic cases after this phase. However, in a large proportion of patients symptoms persist into a post-acute phase and in some may even continue to become chronic. In the post-acute phase, which can last up to 4 months, there is clinical persistence of joint inflammation or relapse after transient improvement. These can lead to musculoskeletal disorders and eventually chronicity of disease. The main symptoms being chronic inflammatory rheumatism that can last for several years in some cases. With the near global reach, debilitating nature and recent outbreaks of CHIKV there has been much research effort put towards combatting it. New antivirals and medications to counteract inflammation are being developed. Development of CHIKV vaccines is also an area with intense research focus.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherCSIRO Publishing
dc.relation.ispartofpagefrom76
dc.relation.ispartofpageto79
dc.relation.ispartofissue2
dc.relation.ispartofjournalMicrobiology Australia
dc.relation.ispartofvolume39
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0605
dc.titleChikungunya: treatments, opportunities and possibilities
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPublished
gro.rights.copyright© 2018 ASM. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorRao, Shambhavi
gro.griffith.authorFreitas, Joseph R.
gro.griffith.authorMahalingam, Suresh


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