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dc.contributor.authorChandrasekera, Erandi
dc.contributor.authorWong, Evan N
dc.contributor.authorSampson, Danuta M
dc.contributor.authorAlonso-Caneiro, David
dc.contributor.authorChen, Fred K
dc.date.accessioned2019-06-09T01:35:51Z
dc.date.available2019-06-09T01:35:51Z
dc.date.issued2018
dc.identifier.issn0146-0404
dc.identifier.doi10.1167/iovs.18-24665
dc.identifier.urihttp://hdl.handle.net/10072/383691
dc.description.abstractPurpose: To determine the influence of choroidal boundary morphology on the accuracy of automated measurements of subfoveal choroidal thickness (SFCT) in swept source optical coherence tomography (SSOCT). Methods: A retrospective image analysis of foveal-centered horizontal line scans from normal and diseased eyes using the Topcon DRI OCT-1 Atlantis SSOCT was conducted. Subfoveal choroid-scleral junction (CSJ) and retina-choroidal junction (RCJ) morphologies were graded by two observers. Automated SFCT (A-SFCT) was compared with manual SFCT (M-SFCT) measurements from Bruch's membrane to the posterior limits of choroidal vessel, hyperreflective stroma, and hyporeflective lamina fusca. Agreement in boundary grading was assessed by Cohen's kappa. A-SFCT and M-SFCT were compared using Bland-Altman analysis and paired t-tests. Results: A total of 200 eyes of 100 patients with a mean (SD) age of 62 (18) years were included. The choroidal vessel, stromal, and lamina fusca boundaries were visible in 100%, 58%, and 38% of the eyes, respectively. Interobserver agreement in RCJ and CSJ grading was high (kappa = 0.974 and 0.851). Mean A-SFCT differed from M-SFCT by only 2 μm at posterior choroidal vessel boundary (P = 0.801). A-SFCT overestimated SFCT at the posterior vessel wall boundary by 17 μm (P = 0.026) and 23 μm (P = 0.001) in the presence of a visible posterior choroidal stroma and lamina fusca, respectively. Conclusions: Automated outer choroidal boundary segmentation tends to identify the posterior limit of the choroidal vessel. Agreement between A-SFCT and M-SFCT is reduced by the presence of posterior stromal layer and lamina fusca. A-SFCT should be interpreted with RCJ and CSJ boundary grading.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
dc.relation.ispartofpagefrom4404
dc.relation.ispartofpageto4412
dc.relation.ispartofissue11
dc.relation.ispartofjournalINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
dc.relation.ispartofvolume59
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode06
dc.titlePosterior Choroidal Stroma Reduces Accuracy of Automated Segmentation of Outer Choroidal Boundary in Swept Source Optical Coherence Tomography
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPublished
gro.rights.copyright© 2018 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorAlonso-Caneiro, David


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