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dc.contributor.authorWoodman-Pieterse, Emily C
dc.contributor.authorRead, Scott A
dc.contributor.authorCollins, Michael J
dc.contributor.authorAlonso-Caneiro, David
dc.date.accessioned2020-03-20T00:59:33Z
dc.date.available2020-03-20T00:59:33Z
dc.date.issued2018
dc.identifier.issn0014-4835
dc.identifier.doi10.1016/j.exer.2018.07.023
dc.identifier.urihttp://hdl.handle.net/10072/383693
dc.description.abstractAlthough a range of changes in anterior segment structures have been documented to occur during accommodation, the quantification of changes in the structure of the anterior sclera during the accommodation process in human subjects has yet to be examined. This study therefore aimed to investigate the presence of short-term changes in anterior scleral thickness associated with accommodation in young adult myopic and emmetropic subjects. Anterior scleral thickness was measured in 20 myopes and 20 emmetropes (mean age 21 ± 2 years) during various accommodation demands (0, 3 and 6 D) with anterior segment optical coherence tomography (AS-OCT). A Badal optometer was mounted in front of the objective lens of the AS-OCT to allow measurements of the anterior temporal sclera (1, 2 and 3 mm posterior to the scleral spur) to be obtained while fixating on an external accommodation stimulus. Anterior scleral thickness was not statistically different between refractive groups at baseline, but thinned significantly with the 6 D accommodation demand (−8 ± 21 μm, p < 0.05), and approached a statistically significant change with the 3 D demand (−6 ± 20 μm, p = 0.066). While both refractive groups thinned by a statistically significant amount at the 1 mm location with the 3 D demand; significant (p < 0.001) refractive group differences occurred at 3 mm, where the thinning found in the myopic group reached statistical significance with both the 3 D (−12 ± 21 μm) and 6 D (−19 ± 17 μm) demands, and the emmetropes showed no significant changes. This demonstrates the first evidence of a small but statistically significant thinning of the anterior sclera during accommodation. These changes were more prominent in myopes, particularly 3 mm posterior to the scleral spur. These regional differences may be associated with previously reported regional variations in ciliary body thickness between refractive groups, regional differences in the contraction of the ciliary muscle with accommodation, or differences in the response of the sclera to these biomechanical forces.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom96
dc.relation.ispartofpageto103
dc.relation.ispartofjournalExperimental Eye Research
dc.relation.ispartofvolume177
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchOphthalmology and optometry
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode3212
dc.titleAnterior scleral thickness changes with accommodation in myopes and emmetropes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorAlonso-Caneiro, David


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