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dc.contributor.authorLang, Tali
dc.contributor.authorLee, Jacinta PW
dc.contributor.authorElgass, Kirstin
dc.contributor.authorPinar, Anita A
dc.contributor.authorTate, Michelle D
dc.contributor.authorAitken, Elizabeth H
dc.contributor.authorFan, Huapeng
dc.contributor.authorCreed, Sarah J
dc.contributor.authorDeen, Nadia S
dc.contributor.authorTraore, Daouda AK
dc.contributor.authorMueller, Ivo
dc.contributor.authorStanisic, Danielle
dc.contributor.authorBaiwog, Francesca S
dc.contributor.authorSkene, Colin
dc.contributor.authorWilce, Matthew CJ
dc.contributor.authorMansell, Ashley
dc.contributor.authorMorand, Eric F
dc.contributor.authorHarris, James
dc.date.accessioned2019-08-13T03:14:28Z
dc.date.available2019-08-13T03:14:28Z
dc.date.issued2018
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/s41467-018-04581-2
dc.identifier.urihttp://hdl.handle.net/10072/383707
dc.description.abstractMacrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show that inhibition of MIF regulates the release of IL-1α, IL-1β, and IL-18, not by affecting transcription or translation of these cytokines, but via activation of the NLRP3 inflammasome. MIF is required for the interaction between NLRP3 and the intermediate filament protein vimentin, which is critical for NLRP3 activation. Further, we demonstrate that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation independent of its role as a cytokine. These data advance our understanding of how MIF regulates inflammation and identify it as a factor critical for NLRP3 inflammasome activation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofjournalNATURE COMMUNICATIONS
dc.relation.ispartofvolume9
dc.subject.fieldofresearchProteomics and metabolomics
dc.subject.fieldofresearchProteins and peptides
dc.subject.fieldofresearchcode310205
dc.subject.fieldofresearchcode340407
dc.titleMacrophage migration inhibitory factor is required for NLRP3 inflammasome activation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorStanisic, Danielle


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