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dc.contributor.authorElsayed, Hassan
dc.contributor.authorNabi, Ghulam
dc.contributor.authorMcKinstry, William J
dc.contributor.authorKhoo, Keith K
dc.contributor.authorMak, Johnson
dc.contributor.authorSalazar, Andres M
dc.contributor.authorTenbusch, Matthias
dc.contributor.authorTemchura, Vladimir
dc.contributor.authorUeberla, Klaus
dc.date.accessioned2019-07-05T12:32:13Z
dc.date.available2019-07-05T12:32:13Z
dc.date.issued2018
dc.identifier.issn0022-538X
dc.identifier.doi10.1128/JVI.00141-18
dc.identifier.urihttp://hdl.handle.net/10072/383776
dc.description.abstractInduction of persistent antibody responses by vaccination is generally thought to depend on efficient help by T follicular helper cells. Since the T helper cell response to HIV Env may not be optimal, we explored the possibility of improving the HIV Env antibody response to virus-like particle (VLP) vaccines by recruiting T helper cells induced by commonly used licensed vaccines to provide help for Env-specific B cells. B cells specific for the surface protein of a VLP can internalize the entire VLP and thus present peptides derived from the surface and core proteins on their major histocompatibility complex class II (MHC-II) molecules. This allows T helper cells specific for the core protein to provide intrastructural help for B cells recognizing the surface protein. Consistently, priming mice with an adjuvanted Gag protein vaccine enhanced the HIV Env antibody response to subsequent booster immunizations with HIV VLPs. To harness T helper cells induced by the licensed Tetanolpur vaccines, HIV VLPs that contained T helper cell epitopes of tetanus toxoid were generated. Tetanol-immunized mice raised stronger antibody responses to immunizations with VLPs containing tetanus toxoid T helper cell epitopes but not to VLPs lacking these epitopes. Depending on the priming immunization, the IgG subtype response to HIV Env after the VLP immunization could also be modified. Thus, harnessing T helper cells induced by other vaccines appears to be a promising approach to improve the HIV Env antibody response to VLP vaccines.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofissue14
dc.relation.ispartofjournalJOURNAL OF VIROLOGY
dc.relation.ispartofvolume92
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.titleIntrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 Mak et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
gro.hasfulltextFull Text
gro.griffith.authorMak, Johnson


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