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  • Sepsis: Changing Definitions, Unchanging Treatment

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    Fraser196413.pdf (286.2Kb)
    Author(s)
    Obonyo, Nchafatso Gikenyi
    Schlapbach, Luregn Jan
    Fraser, John Francis
    Griffith University Author(s)
    Fraser, John F.
    Year published
    2019
    Metadata
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    Abstract
    The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardized criteria for sepsis that can be applied to pediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment ...
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    The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardized criteria for sepsis that can be applied to pediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment strategies to improve clinical outcomes.
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    Journal Title
    FRONTIERS IN PEDIATRICS
    Volume
    6
    DOI
    https://doi.org/10.3389/fped.2018.00425
    Copyright Statement
    Copyright © 2019 Obonyo, Schlapbach and Fraser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Paediatrics
    Other health sciences
    Publication URI
    http://hdl.handle.net/10072/383780
    Collection
    • Journal articles

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