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  • Contribution of cryptic epitopes in designing a group A streptococcal vaccine

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    Author(s)
    Ozberk, Victoria
    Pandey, Manisha
    Good, Michael F
    Griffith University Author(s)
    Good, Michael F.
    Ozberk, Victoria
    Pandey, Manisha
    Year published
    2018
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    Abstract
    A successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there is currently no vaccine available for this organism. Here we review and discuss the significant obstacles to vaccine development, with a focus on how cryptic epitopes may provide a strategy to circumvent the obstacles of antigenic variation.A successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there is currently no vaccine available for this organism. Here we review and discuss the significant obstacles to vaccine development, with a focus on how cryptic epitopes may provide a strategy to circumvent the obstacles of antigenic variation.
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    Journal Title
    Human Vaccines & Immunotherapeutics
    Volume
    14
    Issue
    8
    DOI
    https://doi.org/10.1080/21645515.2018.1462427
    Copyright Statement
    © 2018 Griffith University. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
    Subject
    Immunology
    Medical microbiology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/383799
    Collection
    • Journal articles

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