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  • Analysis of the Preserved Amino Acid Bias in Peptide Profiles of Iron Age Teeth from a Tropical Environment Enable Sexing of Individuals Using Amelogenin MRM

    Author(s)
    Wasinger, Valerie C
    Curnoe, Darren
    Bustamante, Sonia
    Mendoza, Raynold
    Shoocongdej, Rasmi
    Adler, Lewis
    Baker, Andy
    Chintakanon, Kanoknart
    Boel, Ceridwen
    Tacon, Paul SC
    Griffith University Author(s)
    Tacon, Paul S.
    Year published
    2019
    Metadata
    Show full item record
    Abstract
    The first dental proteomic profile of Iron Age individuals (ca. 2000–1000 years B.P.), collected from the site of Long Long Rak rock shelter in northwest Thailand is described. A bias toward the preservation of the positively charged aromatic, and polar amino acids is observed. It is evident that the 212 proteins identified (2 peptide, FDR <1%) comprise a palimpsest of alterations that occurred both ante-mortem and post-mortem. Conservation of amino acids within the taphonomically resistant crystalline matrix enabled the identification of both X and Y chromosome linked amelogenin peptides. A novel multiple reaction monitoring ...
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    The first dental proteomic profile of Iron Age individuals (ca. 2000–1000 years B.P.), collected from the site of Long Long Rak rock shelter in northwest Thailand is described. A bias toward the preservation of the positively charged aromatic, and polar amino acids is observed. It is evident that the 212 proteins identified (2 peptide, FDR <1%) comprise a palimpsest of alterations that occurred both ante-mortem and post-mortem. Conservation of amino acids within the taphonomically resistant crystalline matrix enabled the identification of both X and Y chromosome linked amelogenin peptides. A novel multiple reaction monitoring method using the sex specific amelogenin protein isoforms is described and indicate the teeth are of male origin. Functional analysis shows an enrichment of pathways associated with metabolic disorders and shows a capacity for harboring these conditions prior to death. Stable isotope analysis using carbon isotopes highlights the strongly C 3 based (≈80%) diet of the Long Long Rak cemetery people, which probably comprised rice combined with protein from freshwater fish among other food items. The combination of proteomics and stable isotope analysis provides a complementary strategy for assessing the demography, diet, lifestyle, and possible diseases experienced by ancient populations.
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    Journal Title
    PROTEOMICS
    Volume
    19
    Issue
    5
    DOI
    https://doi.org/10.1002/pmic.201800341
    Subject
    Archaeological science
    Archaeology of Asia, Africa and the Americas
    Publication URI
    http://hdl.handle.net/10072/384016
    Collection
    • Journal articles

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    • Gold Coast
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    First Peoples of Australia
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