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dc.contributor.authorYuan, Dan
dc.contributor.authorSluyter, Ronald
dc.contributor.authorZhao, Qianbin
dc.contributor.authorTang, Shiyang
dc.contributor.authorYan, Sheng
dc.contributor.authorYun, Guolin
dc.contributor.authorLi, Ming
dc.contributor.authorZhang, Jun
dc.contributor.authorLi, Weihua
dc.date.accessioned2019-06-10T01:32:21Z
dc.date.available2019-06-10T01:32:21Z
dc.date.issued2019
dc.identifier.issn1613-4982
dc.identifier.doi10.1007/s10404-019-2204-3
dc.identifier.urihttp://hdl.handle.net/10072/384022
dc.description.abstractThis work investigates particle focusing under Dean-flow-coupled elasto-inertial effects in symmetric serpentine microchannels. A small amount of polymers were added to the sample solution to tune the fluid elasticity, and allow particles to migrate laterally and reach their equilibriums at the centerline of a symmetric serpentine channel under the synthesis effect of elastic, inertial and Dean-flow forces. First, the effects of the flow rates on particle focusing in viscoelastic fluid in serpentine channels were investigated. Then, comparisons with particle focusing in the Newtonian fluid in the serpentine channel and in the viscoelastic fluid in the straight channel were conducted. The elastic effect and the serpentine channel structure could accelerate the particle focusing as well as reduce the channel length. This focusing technique has the potential as a pre-ordering unit in flow cytometry for cell counting, sorting, and analysis. Moreover, focusing behaviour of Jurkat cells in the viscoelastic fluid in this serpentine channel was studied. Finally, the cell viability in the culture medium containing a dissolved polymer and after processing through the serpentine channel was tested. The polymer within this viscoelastic fluid has a negligible effect on cell viability.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofissue3
dc.relation.ispartofjournalMICROFLUIDICS AND NANOFLUIDICS
dc.relation.ispartofvolume23
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchMechanical Engineering
dc.subject.fieldofresearchInterdisciplinary Engineering
dc.subject.fieldofresearchcode1007
dc.subject.fieldofresearchcode0913
dc.subject.fieldofresearchcode0915
dc.titleDean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Springer Berlin Heidelberg. This is an electronic version of an article published in Microfluidics and Nanofluidics, March 2019, 23:41. Microfluidics and Nanofluidics is available online at: http://link.springer.com/ with the open URL of your article.
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gro.griffith.authorZhang, Jun


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