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  • The Association of Mediterranean and DASH Diets with Mortality in Adults on Hemodialysis: The DIET-HD Multinational Cohort Study

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    Author(s)
    Saglimbene, Valeria M
    Wong, Germaine
    Craig, Jonathan C
    Ruospo, Marinella
    Palmer, Suetonia C
    Campbell, Katrina
    Garcia-Larsen, Vanessa
    Natale, Patrizia
    Teixeira-Pinto, Armando
    Carrero, Juan-Jesus
    Stenvinkel, Peter
    Gargano, Letizia
    Murgo, Angelo M
    Johnson, David W
    Tonelli, Marcello
    Gelfman, Ruben
    Celia, Eduardo
    Ecder, Tevfik
    Bernat, Amparo G
    Del Castillo, Domingo
    Timofte, Delia
    Torok, Marietta
    Bednarek-Skublewska, Anna
    Dulawa, Jan
    Stroumza, Paul
    Hoischen, Susanne
    Hansis, Martin
    Fabricius, Elisabeth
    Felaco, Paolo
    Wollheim, Charlotta
    Hegbrant, Jorgen
    Strippoli, Giovanni FM
    Griffith University Author(s)
    Campbell, Katrina
    Year published
    2018
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    Abstract
    Background: Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets associate with lower cardiovascular and all-cause mortality in the general population, but the benefits for patients on hemodialysis are uncertain. Methods: Mediterranean and DASH diet scores were derived from the GA2LEN Food Frequency Questionnaire within the DIET-HD Study, a multinational cohort study of 9757 adults on hemodialysis. We conducted adjusted Cox regression analyses clustered by country to evaluate the association between diet score tertiles and all-cause and cardiovascular mortality (the lowest tertile was the reference ...
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    Background: Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets associate with lower cardiovascular and all-cause mortality in the general population, but the benefits for patients on hemodialysis are uncertain. Methods: Mediterranean and DASH diet scores were derived from the GA2LEN Food Frequency Questionnaire within the DIET-HD Study, a multinational cohort study of 9757 adults on hemodialysis. We conducted adjusted Cox regression analyses clustered by country to evaluate the association between diet score tertiles and all-cause and cardiovascular mortality (the lowest tertile was the reference category). Results During the median 2.7-year follow-up, 2087 deaths (829 cardiovascular deaths) occurred. The adjusted hazard ratios (95% confidence intervals) for the middle and highest Mediterranean diet score tertiles were 1.20 (1.01 to 1.41) and 1.14 (0.90 to 1.43), respectively, for cardiovascular mortality and 1.10 (0.99 to 1.22) and 1.01 (0.88 to 1.17), respectively, for all-cause mortality. Corresponding estimates for the same DASH diet score tertiles were 1.01 (0.85 to 1.21) and 1.19 (0.99 to 1.43), respectively, for cardiovascular mortality and 1.03 (0.92 to 1.15) and 1.00 (0.89 to 1.12), respectively, for all-cause mortality. The association between DASH diet score and all-cause death was modified by age (P=0.03); adjusted hazard ratios for the middle and highest DASH diet score tertiles were 1.02 (0.81 to 1.29) and 0.70 (0.53 to 0.94), respectively, for younger patients (#60 years old) and 1.05 (0.93 to 1.19) and 1.08 (0.95 to 1.23), respectively, for older patients. Conclusions: Mediterranean and DASH diets did not associate with cardiovascular or total mortality in hemodialysis.
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    Journal Title
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    Volume
    29
    Issue
    6
    DOI
    https://doi.org/10.1681/ASN.2018010008
    Copyright Statement
    © 2018 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/384081
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    • Journal articles

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