Show simple item record

dc.contributor.authorMridha, Naim
dc.contributor.authorSubhaharan, Deloshaan
dc.contributor.authorNiranjan, Selvanayagam
dc.contributor.authorRashid, Mohammed K
dc.contributor.authorPsaltis, Peter
dc.contributor.authorSingh, Kuljit
dc.date.accessioned2019-07-04T12:33:51Z
dc.date.available2019-07-04T12:33:51Z
dc.date.issued2019
dc.identifier.issn2058-5225
dc.identifier.doi10.1093/ehjqcco/qcy036
dc.identifier.urihttp://hdl.handle.net/10072/384323
dc.description.abstractAIMS: The durable polymer (DP) of a drug-eluting stent (DES) serves no function once drug elution is complete. To ascertain the benefits of bioabsorbable polymer (BP) over DP-DESs requires a longer follow-up period, to overcome the time taken for polymer absorption. The primary aim of this meta-analysis was to compare the safety and efficacy of BP-DES with the DP-DES over mid (2 years) to long-term (3-5 years) follow-up. METHODS AND RESULTS: A thorough computer-based search was performed using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases. We only included randomized controlled studies comparing clinical outcomes between BP-DESs and DP-DESs. Only studies where data were available for a minimum of 2 years were included. A separate analysis of 2-year outcomes and 3- to 5-year outcomes were conducted. Data from 6 and 8 studies were included in 3- to 5-year and 2-year follow-up, respectively. There were no differences between stent groups in cardiac mortality, stent thrombosis (ST), target lesion revascularization, target vessel failure, and reinfarction rates for either 2-year or 3- to 5-year follow-up. Subgroup analysis according to strut thickness (<100 µm, >100 µm) of BP-DES demonstrated similar results. The analyses of ST and very late ST favoured BP-DESs but did not reach statistically significant level. CONCLUSION: There were no differences in clinical outcomes between BP-DESs and DP-DESs over mid- and long-term follow-up.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.relation.ispartoflocationEngland
dc.relation.ispartofpagefrom105
dc.relation.ispartofpageto113
dc.relation.ispartofissue2
dc.relation.ispartofjournalEUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
dc.relation.ispartofvolume5
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.titleA meta-analysis of randomized controlled trials to compare long-term clinical outcomes of bioabsorbable polymer and durable polymer drug-eluting stents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSingh, Kuljit
gro.griffith.authorMridha, Naim
gro.griffith.authorSubhaharan, Deloshaan
gro.griffith.authorNiranjan, Selvanayagam


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record