dc.contributor.author | Mridha, Naim | |
dc.contributor.author | Subhaharan, Deloshaan | |
dc.contributor.author | Niranjan, Selvanayagam | |
dc.contributor.author | Rashid, Mohammed K | |
dc.contributor.author | Psaltis, Peter | |
dc.contributor.author | Singh, Kuljit | |
dc.date.accessioned | 2019-07-04T12:33:51Z | |
dc.date.available | 2019-07-04T12:33:51Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2058-5225 | |
dc.identifier.doi | 10.1093/ehjqcco/qcy036 | |
dc.identifier.uri | http://hdl.handle.net/10072/384323 | |
dc.description.abstract | AIMS: The durable polymer (DP) of a drug-eluting stent (DES) serves no function once drug elution is complete. To ascertain the benefits of bioabsorbable polymer (BP) over DP-DESs requires a longer follow-up period, to overcome the time taken for polymer absorption. The primary aim of this meta-analysis was to compare the safety and efficacy of BP-DES with the DP-DES over mid (2 years) to long-term (3-5 years) follow-up. METHODS AND RESULTS: A thorough computer-based search was performed using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases. We only included randomized controlled studies comparing clinical outcomes between BP-DESs and DP-DESs. Only studies where data were available for a minimum of 2 years were included. A separate analysis of 2-year outcomes and 3- to 5-year outcomes were conducted. Data from 6 and 8 studies were included in 3- to 5-year and 2-year follow-up, respectively. There were no differences between stent groups in cardiac mortality, stent thrombosis (ST), target lesion revascularization, target vessel failure, and reinfarction rates for either 2-year or 3- to 5-year follow-up. Subgroup analysis according to strut thickness (<100 µm, >100 µm) of BP-DES demonstrated similar results. The analyses of ST and very late ST favoured BP-DESs but did not reach statistically significant level. CONCLUSION: There were no differences in clinical outcomes between BP-DESs and DP-DESs over mid- and long-term follow-up. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.relation.ispartoflocation | England | |
dc.relation.ispartofpagefrom | 105 | |
dc.relation.ispartofpageto | 113 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES | |
dc.relation.ispartofvolume | 5 | |
dc.subject.fieldofresearch | Cardiovascular medicine and haematology | |
dc.subject.fieldofresearchcode | 3201 | |
dc.title | A meta-analysis of randomized controlled trials to compare long-term clinical outcomes of bioabsorbable polymer and durable polymer drug-eluting stents | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Singh, Kuljit | |
gro.griffith.author | Mridha, Naim | |
gro.griffith.author | Subhaharan, Deloshaan | |
gro.griffith.author | Niranjan, Selvanayagam | |