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dc.contributor.authorBasu Mallik, Sanchari
dc.contributor.authorJayashree, BS
dc.contributor.authorShenoy, Rekha R
dc.date.accessioned2019-06-09T01:34:32Z
dc.date.available2019-06-09T01:34:32Z
dc.date.issued2018
dc.identifier.issn1873-460X
dc.identifier.doi10.1016/j.jdiacomp.2018.01.015
dc.identifier.urihttp://hdl.handle.net/10072/384385
dc.description.abstractDiabetes is a chronic metabolic disorder that poses a global burden to healthcare. Increasing incidence of diabetes-related complications in the affected population includes a delay in wound healing that often results in non-traumatic limb amputations. Owing to the intricacies of the healing process and crosstalk between the multitude of participating cells, the identification of hyperglycaemia-induced changes at both cellular and molecular levels poses a challenge. Macrophages are one of the key participants in wound healing and continue to exert functional changes at the wound site since the time of injury. In the present review, we discuss the role of these cells and their aberrant functions in diabetic wounds. We have extensively studied the process of macrophage polarization (MP) and its modulation through epigenetic modifications. Data from both pre-clinical and clinical studies on diabetes have co-related hyperglycaemia induced changes in gene expression to an increased incidence of diabetic complications. Hyperglycaemia and oxidative stress, create an environment prone to changes in the epigenetic code, that is manifested as an altered inflammatory gene expression. Here, we have attempted to understand the different epigenetic modulations that possibly contribute towards dysregulated MP, resulting in delayed wound healing.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartoflocationUnited States
dc.relation.ispartofpagefrom524
dc.relation.ispartofpageto530
dc.relation.ispartofissue5
dc.relation.ispartofjournalJ Diabetes Complications
dc.relation.ispartofvolume32
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleEpigenetic modulation of macrophage polarization- perspectives in diabetic wounds.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBasu Mallik, Sanchari


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