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  • Using UHPLC-MS Profiling for the Discovery of New Dihydro-beta-Agarofurans from Australian Celastraceae Plant Extracts

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    Author(s)
    Wibowo, Mario
    Forster, Paul I
    Guymer, Gordon P
    Hofmann, Andreas
    Davis, Rohan A
    Griffith University Author(s)
    Hofmann, Andreas
    Wibowo, Mario
    Davis, Rohan A.
    Year published
    2019
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    Abstract
    An analytical method using UHPLC-MS was developed and applied to 16 crude CH2Cl2 extracts from Australian Celastraceae plants; the endemic plant materials were accessed from Griffith University’s NatureBank resource and included bark, fruit, leaf, root, twig and mixed samples, all of which were collected from Queensland, Australia. The generated UHPLC-MS data were analysed and dereplicated using the scientific databases Dictionary of Natural Products and SciFinder Scholar in order to potentially identify new dihydro-β-agarofurans from local Celastraceae plants. These investigations led to the large-scale extraction and ...
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    An analytical method using UHPLC-MS was developed and applied to 16 crude CH2Cl2 extracts from Australian Celastraceae plants; the endemic plant materials were accessed from Griffith University’s NatureBank resource and included bark, fruit, leaf, root, twig and mixed samples, all of which were collected from Queensland, Australia. The generated UHPLC-MS data were analysed and dereplicated using the scientific databases Dictionary of Natural Products and SciFinder Scholar in order to potentially identify new dihydro-β-agarofurans from local Celastraceae plants. These investigations led to the large-scale extraction and isolation work on a prioritised fruit sample that belonged to the rainforest plant Denhamia celastroides. Chemical investigations resulted in the purification of four new natural products, denhaminols O–R (1–4), along with the related and known compound, denhaminol G (5). The structures of all the new compounds were determined via detailed analysis of NMR and MS data.
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    Journal Title
    MOLECULES
    Volume
    24
    Issue
    5
    DOI
    https://doi.org/10.3390/molecules24050859
    Copyright Statement
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Theoretical and computational chemistry
    Publication URI
    http://hdl.handle.net/10072/384430
    Collection
    • Journal articles

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