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dc.contributor.authorWibowo, Mario
dc.contributor.authorForster, Paul I
dc.contributor.authorGuymer, Gordon P
dc.contributor.authorHofmann, Andreas
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2019-07-19T05:03:21Z
dc.date.available2019-07-19T05:03:21Z
dc.date.issued2019
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules24050859
dc.identifier.urihttp://hdl.handle.net/10072/384430
dc.description.abstractAn analytical method using UHPLC-MS was developed and applied to 16 crude CH2Cl2 extracts from Australian Celastraceae plants; the endemic plant materials were accessed from Griffith University’s NatureBank resource and included bark, fruit, leaf, root, twig and mixed samples, all of which were collected from Queensland, Australia. The generated UHPLC-MS data were analysed and dereplicated using the scientific databases Dictionary of Natural Products and SciFinder Scholar in order to potentially identify new dihydro-β-agarofurans from local Celastraceae plants. These investigations led to the large-scale extraction and isolation work on a prioritised fruit sample that belonged to the rainforest plant Denhamia celastroides. Chemical investigations resulted in the purification of four new natural products, denhaminols O–R (1–4), along with the related and known compound, denhaminol G (5). The structures of all the new compounds were determined via detailed analysis of NMR and MS data.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto12
dc.relation.ispartofissue5
dc.relation.ispartofjournalMOLECULES
dc.relation.ispartofvolume24
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3407
dc.titleUsing UHPLC-MS Profiling for the Discovery of New Dihydro-beta-Agarofurans from Australian Celastraceae Plant Extracts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas
gro.griffith.authorWibowo, Mario
gro.griffith.authorDavis, Rohan A.


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