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dc.contributor.authorJiang, G
dc.contributor.authorLiu, M
dc.contributor.authorFang, D
dc.contributor.authorTan, P
dc.contributor.authorHuang, M
dc.contributor.authorZhou, T
dc.contributor.authorJiang, Z
dc.contributor.authorXu, Z
dc.contributor.authorWang, Z
dc.date.accessioned2019-06-14T01:32:13Z
dc.date.available2019-06-14T01:32:13Z
dc.date.issued2018
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/c8ra00326b
dc.identifier.urihttp://hdl.handle.net/10072/384561
dc.description.abstractAn N,N-diisopropylethylamine promoted solvent-free Ramachary reductive coupling/alkylation (RRC/A) reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates has been developed. A series of 2,2-disubstituted ethyl cyanoacetates were synthesized in one pot by the RRC/A reaction of commercially available aldehydes, ethyl cyanacetates, alkyl halides and Hantzsch ester. A solvent free two step multicomponent reaction has also been developed for the preparation of 2,2-dialkylated malononitriles and 2,2-dialkylated 4-nitrophenyl acetonitriles. All the designed RRC/A products could be easily obtained with good yields by these methods.
dc.description.peerreviewedYes
dc.publisherROYAL SOCIETY OF CHEMISTRY
dc.relation.ispartofpagefrom8961
dc.relation.ispartofpageto8964
dc.relation.ispartofissue16
dc.relation.ispartofjournalRSC Advances
dc.relation.ispartofvolume8
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode03
dc.titleA base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyrightThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
gro.hasfulltextFull Text
gro.griffith.authorXu, Zhihong


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